| Gene Symbol | IL1RAPL1 |
|---|---|
| Entrez Gene | 11141 |
| Alt Symbol | IL1R8, IL1RAPL, MRX10, MRX21, MRX34, OPHN4, TIGIRR-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 1 receptor accessory protein-like 1 |
| Other Description | IL-1-RAPL-1|IL-1RAPL-1|IL1RAPL-1|X-linked interleukin-1 receptor accessory protein-like 1|interleukin 1 receptor-8|interleukin-1 receptor accessory protein-like 1|mental retardation, X-linked 10|oligophrenin-4|three immunoglobulin domain-containing IL-1 receptor-related 2 |
| Swissprots | A0AVG4 Q9NZN1 Q9UJ53 |
| Accessions | BAC80450 BAC80451 BAC80452 BAC80453 BAC80454 BAC80455 BAC80456 BAC80457 BAC80458 BAC80459 BAC80460 BAC80461 BAC80462 BAC80463 BAC80464 BAC80465 BAC80466 BAC80467 BAC80468 BAC80469 EAW99046 Q9NZN1 AB102650 BAC81119 AF181284 AAF59411 AF284435 AAG21369 AJ243874 CAB56046 BC111918 AAI11919 BC126345 AAI26346 BC126347 AAI26348 DN994486 HQ258589 ADR83342 KJ534871 AHW56511 XM_005274441 XP_005274498 XM_011545445 XP_011543747 NM_014271 NP_055086 |
| Function | May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. {ECO:0000269|PubMed:12783849, ECO:0000269|PubMed:15123616}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:12783849}; Single-pass type I membrane protein {ECO:0000269|PubMed:12783849}. Cytoplasm {ECO:0000269|PubMed:12783849}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=May localize to the cell body and growth cones of dendrite-like processes. {ECO:0000250}. |
| Tissue Specificity | Detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal liver. {ECO:0000269|PubMed:10471494, ECO:0000269|PubMed:10882729}. |