PLA2G6

Gene Symbol	PLA2G6
Entrez Gene	8398
Alt Symbol	CaI-PLA2, GVI, INAD1, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9, iPLA2, iPLA2beta
Species	Human
Gene Type	protein-coding
Description	phospholipase A2, group VI (cytosolic, calcium-independent)
Other Description	85 kDa calcium-independent phospholipase A2|85/88 kDa calcium-independent phospholipase A2|GVI PLA2|calcium-independent phospholipase A2|cytosolic, calcium-independent phospholipase A2|group VI phospholipase A2|iPLA2-beta|intracellular membrane-associated calcium-independent phospholipase A2 beta|neurodegeneration with brain iron accumulation 2|patatin-like phospholipase domain containing 9|patatin-like phospholipase domain-containing protein 9
Swissprots	O60733 Q9UG29 O75645 A8K597 Q9UIT0 Q9Y671 B0QYE8 Q8N452
Accessions	AAD30424 AAF34728 AAR92478 EAW60219 EAW60220 O60733 AF064594 AAC97486 AF102988 AAD41722 AF102989 AAD41723 AK001290 AK096521 BAG53314 AK128862 AK290825 BAF83514 AK291212 BAF83901 AK300459 BAH13289 AK308308 AL080187 CAB45768 BC034592 BC036742 AAH36742 BC051904 AAH51904 CR456543 CAG30429 CU013143 CAK54574 CU013431 CAK54873 XM_005261764 XP_005261821 XM_005261765 XP_005261822 XM_005261766 XP_005261823 XM_005261771 XP_005261828 XM_006724332 XP_006724395 XM_011530422 XP_011528724 XM_011530423 XP_011528725 XM_011530424 XP_011528726 XM_011530425 XP_011528727 XM_011530426 XP_011528728 XM_011530427 XP_011528729 XM_011530428 XP_011528730 XR_244390 XR_244392 XR_430411 XR_430412 XR_937937 XR_937938 XR_937939 XR_937940 NM_001004426 NP_001004426 NM_001199562 NP_001186491 NM_003560 NP_003551
Function	Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods.
Subcellular Location	Isoform LH-iPLA2: Membrane; Peripheral membrane protein. Note=Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes.
Tissue Specificity	Four different transcripts were found to be expressed in a distinct tissue distribution.
Top Pathways	Fc gamma R-mediated phagocytosis, Vascular smooth muscle contraction, Inflammatory mediator regulation of TRP channels, Ether lipid metabolism, Glycerophospholipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PLA2G6 293T Cell Transient Overexpression Lysate(Denatured) - H00008398-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PLA2G6 overexpression lysate - LY400377 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PLA2G6 overexpression lysate - LY418601 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PLA2G6 overexpression lysate - LY429150 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PLA2G6 293 Cell Lysate - 400403 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PLA2G6 Overexpression Lysate (Denatured) - H00008398-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

PLA2G6 Overexpression Lysate (Native) - NBL1-14476 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

group VI iPLA 2 (h): 293T Lysate - sc-116309 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

PLA2G6 Over-expression Lysate Product - GWB-21F11C from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Panoply™ Human PLA2G6 Knockdown Stable Cell Line - CSC-DC011878 from Creative biogene Category Cell Line Species Human

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