| Gene Symbol |
Arhgef1
|
| Entrez Gene |
16801
|
| Alt Symbol |
Lbcl2, Lsc
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
Rho guanine nucleotide exchange factor (GEF) 1
|
| Other Description |
lbc's second cousin|lymphoid blast crisis like 2|lymphoid blast crisis-like 2|rho guanine nucleotide exchange factor 1
|
| Swissprots |
Q80YE9 Q91VL3 O89074 Q3T9Q7 Q80YE8 Q61210
|
| Accessions |
EDL24302 EDL24303 EDL24304 EDL24305 EDL24306 Q61210 AK012156 AK040093 BAC30509 AK043027 AK051518 AK131181 BAD21431 AK157056 BAE33947 AK162482 AK172354 BAE42963 AK195489 AK199220 AK199940 AK201417 AK203844 AK204902 AK211978 AK218306 AY246272 AAO91658 AY246273 AAO91659 BB840025 BC012488 AAH12488 BY323306 CA320228 CF169826 CV783191 U58203 AAC52693 U89421 AAC36527 XM_006539564 XP_006539627 XM_006539565 XP_006539628 XR_391047 NM_001130150 NP_001123622 NM_001130151 NP_001123623 NM_001130152 NP_001123624 NM_001130153 NP_001123625 NM_008488 NP_032514
|
| Function |
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation. Isoform 3 and isoform 4 do not homooligomerize and show an enhanced RhoGEF activity. {ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:8910315}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Translocated to the membrane by activated GNA13 or LPA stimulation. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:8702517}.
|
| Top Pathways |
Vascular smooth muscle contraction, Proteoglycans in cancer, Regulation of actin cytoskeleton
|