Arhgef1

Gene Symbol Arhgef1
Entrez Gene 16801
Alt Symbol Lbcl2, Lsc
Species Mouse
Gene Type protein-coding
Description Rho guanine nucleotide exchange factor (GEF) 1
Other Description lbc's second cousin|lymphoid blast crisis like 2|lymphoid blast crisis-like 2|rho guanine nucleotide exchange factor 1
Swissprots Q80YE9 Q91VL3 O89074 Q3T9Q7 Q80YE8 Q61210
Accessions EDL24302 EDL24303 EDL24304 EDL24305 EDL24306 Q61210 AK012156 AK040093 BAC30509 AK043027 AK051518 AK131181 BAD21431 AK157056 BAE33947 AK162482 AK172354 BAE42963 AK195489 AK199220 AK199940 AK201417 AK203844 AK204902 AK211978 AK218306 AY246272 AAO91658 AY246273 AAO91659 BB840025 BC012488 AAH12488 BY323306 CA320228 CF169826 CV783191 U58203 AAC52693 U89421 AAC36527 XM_006539564 XP_006539627 XM_006539565 XP_006539628 XR_391047 NM_001130150 NP_001123622 NM_001130151 NP_001123623 NM_001130152 NP_001123624 NM_001130153 NP_001123625 NM_008488 NP_032514
Function Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation. Isoform 3 and isoform 4 do not homooligomerize and show an enhanced RhoGEF activity. {ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:8910315}.
Subcellular Location Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Translocated to the membrane by activated GNA13 or LPA stimulation. {ECO:0000250}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:8702517}.
Top Pathways Vascular smooth muscle contraction, Proteoglycans in cancer, Regulation of actin cytoskeleton

Lsc CRISPR/Cas9 KO Plasmid (m) - sc-421392 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Lsc HDR Plasmid (m) - sc-421392-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Lsc Double Nickase Plasmid (m) - sc-421392-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Lsc Double Nickase Plasmid (m2) - sc-421392-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Lsc CRISPR Activation Plasmid (m) - sc-421392-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Lsc CRISPR Activation Plasmid (m2) - sc-421392-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Lsc Lentiviral Activation Particles (m) - sc-421392-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Lsc Lentiviral Activation Particles (m2) - sc-421392-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Lsc siRNA (m) - sc-41725 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Lsc shRNA Plasmid (m) - sc-41725-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Lsc shRNA (m) Lentiviral Particles - sc-41725-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU054021 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN26949 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26949 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ARHGEF1 siRNA (Mouse) - CRM2310 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

ARHGEF1 - MBS8227280 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse ARHGEF1 (NM_008488.2) - SHH239678 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse ARHGEF1 siRNA - orb281786 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

ARHGEF1 shRNA Plasmid (Mouse) - CHM2310 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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