EFNA1

Gene Symbol	EFNA1
Entrez Gene	1942
Alt Symbol	B61, ECKLG, EFL1, EPLG1, LERK-1, LERK1, TNFAIP4
Species	Human
Gene Type	protein-coding
Description	ephrin-A1
Other Description	TNF alpha-induced protein 4|eph-related receptor tyrosine kinase ligand 1|immediate early response protein B61|ligand of eph-related kinase 1|tumor necrosis factor alpha-induced protein 4|tumor necrosis factor, alpha-induced protein 4
Swissprots	Q5SR60 D3DV86 Q8N578 Q6I9T9 Q5SR61 P20827
Accessions	CAX86883 CAX86884 EAW53131 EAW53132 EAW53133 EAW53134 EAW53135 P20827 AK057845 AK289589 BAF82278 AK308965 AK311677 AK313117 BAG35938 AL833641 AW274944 BC032698 AAH32698 BC095432 AAH95432 BC150578 CR457416 CAG33697 DQ890722 ABM81648 DQ893900 ABM84826 M57730 AAA58388 XM_005244940 XP_005244997 NM_004428 NP_004419 NM_182685 NP_872626
Function	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. {ECO:0000269|P
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18794797}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:18794797}.
Tissue Specificity	Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). {ECO:0000269|PubMed:17332925}.
Top Pathways	Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Ephrin A1 full length protein - ab181919 from Abcam Category Protein Prices $357.00 Sizes 100 µg Source HEK 293 cells Species Human

Human Ephrin A1 full length protein - ab112282 from Abcam Category Protein Source Wheat germ Species Human

Human Ephrin A1 full length protein - ab113867 from Abcam Category Protein Source E. coli Species Human

Human Ephrin A1 protein fragment - ab185393 from Abcam Category Protein Source Mammalian Species Human

Mouse Ephrin A1 full length protein - ab185856 from Abcam Category Protein Source Mammalian Species Mouse

EFNA1 / Ephrin A1 Antibody Blocking Peptide - LS-E27510 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Ephrin-A1 Recombinant Protein - H00001942-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Ephrin-A1 Partial Recombinant Protein - H00001942-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Ephrin-A1 Protein - NBP1-72518 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Recombinant Human Ephrin-A1 Fc Chimera, CF - 6417-A1-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Rat Ephrin-A1 (OPCA00073) - OPCA00073 from Aviva Systems Biology Category Protein Prices $198.00 Sizes 50 µg Species Rat

Recombinant rat Ephrin-A1 (OPCA00074) - OPCA00074 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Rat

Recombinant Rat Ephrin-A1 (OPCA01231) - OPCA01231 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Rat

MAP1LC3A Protein (OPPA01388) - OPPA01388 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human EFNA1 protein - orb246334 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human Ephrin-A1 protein - orb180259 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source Human Cells Species Human

Human EFNA1 protein - orb168270 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

Human Ephrin-A1 protein - orb180260 from Biorbyt Category Protein Prices $306.00, $400.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Ephrin A1 Peptide - AC21-2333-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Ephrin-A1 (19-182, His-tag) - AR50104PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

Ephrin-A1 (19-182, His-tag) - AR50104PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

Ephrin-A1 - H00001942-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Ephrin-A1 - H00001942-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Ephrin-A1 - H00001942-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Ephrin-A1 - H00001942-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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