EFNA1
| Gene Symbol | EFNA1 |
|---|---|
| Entrez Gene | 1942 |
| Alt Symbol | B61, ECKLG, EFL1, EPLG1, LERK-1, LERK1, TNFAIP4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ephrin-A1 |
| Other Description | TNF alpha-induced protein 4|eph-related receptor tyrosine kinase ligand 1|immediate early response protein B61|ligand of eph-related kinase 1|tumor necrosis factor alpha-induced protein 4|tumor necrosis factor, alpha-induced protein 4 |
| Swissprots | Q5SR60 D3DV86 Q8N578 Q6I9T9 Q5SR61 P20827 |
| Accessions | CAX86883 CAX86884 EAW53131 EAW53132 EAW53133 EAW53134 EAW53135 P20827 AK057845 AK289589 BAF82278 AK308965 AK311677 AK313117 BAG35938 AL833641 AW274944 BC032698 AAH32698 BC095432 AAH95432 BC150578 CR457416 CAG33697 DQ890722 ABM81648 DQ893900 ABM84826 M57730 AAA58388 XM_005244940 XP_005244997 NM_004428 NP_004419 NM_182685 NP_872626 |
| Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. {ECO:0000269|P |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:18794797}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:18794797}. |
| Tissue Specificity | Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). {ECO:0000269|PubMed:17332925}. |
| Top Pathways | Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway |
ephrin-A1 CRISPR/Cas9 KO Plasmid (h) - sc-401309 from Santa Cruz Biotechnology
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ephrin-A1 HDR Plasmid (h) - sc-401309-HDR from Santa Cruz Biotechnology
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ephrin-A1 Double Nickase Plasmid (h) - sc-401309-NIC from Santa Cruz Biotechnology
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ephrin-A1 Double Nickase Plasmid (h2) - sc-401309-NIC-2 from Santa Cruz Biotechnology
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ephrin-A1 CRISPR Activation Plasmid (h) - sc-401309-ACT from Santa Cruz Biotechnology
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ephrin-A1 CRISPR Activation Plasmid (h2) - sc-401309-ACT-2 from Santa Cruz Biotechnology
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ephrin-A1 Lentiviral Activation Particles (h) - sc-401309-LAC from Santa Cruz Biotechnology
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ephrin-A1 Lentiviral Activation Particles (h2) - sc-401309-LAC-2 from Santa Cruz Biotechnology
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ephrin-A1 siRNA (h) - sc-39426 from Santa Cruz Biotechnology
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ephrin-A1 shRNA Plasmid (h) - sc-39426-SH from Santa Cruz Biotechnology
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ephrin-A1 shRNA (h) Lentiviral Particles - sc-39426-V from Santa Cruz Biotechnology
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Ephrin-A1 RNAi - H00001942-R01 from Novus Biologicals
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Ephrin-A1 RNAi - H00001942-R02 from Novus Biologicals
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MISSION® esiRNA - EHU065371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7694 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7694 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07157 from Sigma-Aldrich
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EFNA1 siRNA (Human) - CRH1339 from Cohesion Biosciences
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EFNA1 - MBS8225184 from MyBioSource
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shRNA set against Human EFNA1 (NM_182685.1) - SHH283621 from Creative biogene
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shRNA set against Human EFNA1(NM_004428.2) - SHH025625 from Creative biogene
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shRNA set against Human EFNA1(NM_182685.1) - SHH025643 from Creative biogene
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Human EFNA1 siRNA - orb261841 from Biorbyt
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EFNA1 shRNA Plasmid (Human) - CHH1339 from Cohesion Biosciences
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EFNA1 miRNA 3'UTR clone - MiUTR1H-03124 from Creative biogene
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