| Gene Symbol |
PML
|
| Entrez Gene |
5371
|
| Alt Symbol |
MYL, PP8675, RNF71, TRIM19
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
promyelocytic leukemia
|
| Other Description |
RING finger protein 71|probable transcription factor PML|promyelocytic leukemia protein|promyelocytic leukemia, inducer of|protein PML|tripartite motif protein TRIM19|tripartite motif-containing protein 19
|
| Swissprots |
Q00755 Q9BZY2 P29593 E9PBR7 Q8WUA0 Q9BWP7 Q9BZX9 Q96S41 Q15959 Q9BZY0 Q9BZX6 Q9BZX7 P29591 P29592 P29590 Q9BZX8 Q9BPW2 Q59FP9 Q9BZY3
|
| Accessions |
AAB29490 AAD13865 CAA46026 EAW77946 EAW77947 P29590 AB208950 BAD92187 AB209051 BAD92288 AB209411 BAD92648 AF230401 AAG50180 AF230402 AAG50181 AF230403 AAG50182 AF230404 AAG50183 AF230405 AAG50184 AF230406 AAG50185 AF230407 AAG50186 AF230408 AAG50187 AF230409 AAG50188 AF230410 AAG50189 AF230411 AAG50190 AF370432 AAQ15268 AF388193 AF388194 AK026871 AK096663 AK300256 BAG62021 AK300951 BAG62579 BC000080 AAH00080 BC020994 AAH20994 BC034251 BC139795 AAI39796 BF510860 BT009911 AAP88913 BX647287 EF535849 M73778 AAA60125 M79462 AAA60388 M79463 AAA60351 M79464 AAA60390 M80185 AAA60352 S50913 AAB19601 X63131 CAA44841 NM_002675 NP_002666 NM_033238 NP_150241 NM_033239 NP_150242 NM_033240 NP_150243 NM_033244 NP_150247 NM_033246 NP_150249 NM_033247 NP_150250 NM_033249 NP_150252 NM_033250 NP_150253
|
| Function |
Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, reg
|
| Subcellular Location |
Nucleus. Nucleus, nucleoplasm. Cytoplasm. Nucleus, PML body. Nucleus, nucleolus. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform PML-1 can shuttle between the nucleus and cytoplasm. Isoform PML-2, isoform PML-3, isoform PML-4, isoform PML-5 and isoform PML-6 are nuclear isoforms whereas isoform PML-7 and isoform PML-14 lacking the nuclear localization signal are cytoplasmic isoforms. Detected in the nucleolus after DNA damage. Acetylation at Lys-487 is essential for its nuclear localization. Within the nucleus, most of PML is expressed in the diffuse nuclear fraction of the nucleoplasm and only a small fraction is found in the matrix- associated nuclear bodies (PML-NBs). The transfer of PML from the nucleoplasm to PML-NBs depends on its phosphorylation and sumoylation. The B1 box and the RING finger are also required for the local
|
| Top Pathways |
Ubiquitin mediated proteolysis, Acute myeloid leukemia, Endocytosis, Influenza A, Herpes simplex infection
|