CTH

Gene Symbol CTH
Entrez Gene 1491
Alt Symbol -
Species Human
Gene Type protein-coding
Description cystathionine gamma-lyase
Other Description cystathionase (cystathionine gamma-lyase)|cysteine desulfhydrase|cysteine-protein sulfhydrase|gamma-cystathionase|homoserine deaminase|homoserine dehydratase
Swissprots Q53Y79 E9PDV0 P32929 Q9H4W7 Q53FB3 Q9H4W8 B4E1R2
Accessions EAX06450 EAX06451 P32929 AK223376 BAD97096 AK303946 BAG64874 AK310269 BC015807 AAH15807 BT006882 AAP35528 DB466459 EU832313 ACE87570 EU832398 ACE86883 S52028 AAB24699 S52784 AAB24700 XM_005270509 XP_005270566 XM_011540787 XP_011539089 NM_001190463 NP_001177392 NM_001902 NP_001893 NM_153742 NP_714964
Function Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. {ECO:0000269|PubMed:19019829, ECO:0000269|PubMed:19261609, ECO:0000269|PubMed:22169477}.
Subcellular Location Cytoplasm.
Top Pathways Glycine, serine and threonine metabolism, Cysteine and methionine metabolism, Selenocompound metabolism, Biosynthesis of amino acids

Human CTH,CSE,Cystathionase Gene - orb142692 from Biorbyt

Prices $255.00
Sizes 10 μg
Species Human

Human-CTH-cDNA-Clone - DC04196 from Abgent, a WuXi AppTec company

Prices $546.75
Sizes 10 µg
Species Human
Accession BC015807

CTH - MBS1270446 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC015807

Human CTH ORF Clone(NM_001190463.1) - CDCR357961 from Creative Biomart

Species Human
Accession NM_001190463.1

Human CTH ORF Clone(NM_001190463.1) - CDCR357963 from Creative Biomart

Species Human
Accession NM_001190463.1

Human CTH Gene cDNA Clone (full-length ORF Clone) - HG14190-G from Sino Biological

Species Human
Accession BC015807

Human CTH natural ORF mammalian expression plasmid, C-HA tag - HG14190-CY from Sino Biological

Species Human
Accession BC015807

Human CTH natural ORF mammalian expression plasmid, N-His tag - HG14190-NH from Sino Biological

Species Human
Accession BC015807

Human CTH natural ORF mammalian expression plasmid, C-OFPSpark tag - HG14190-ACR from Sino Biological

Species Human
Accession BC015807

Human CTH natural ORF mammalian expression plasmid, N-OFPSpark tag - HG14190-ANR from Sino Biological

Species Human
Accession BC015807

Human CTH natural ORF mammalian expression plasmid, N-GFPSpark tag - HG14190-ANG from Sino Biological

Species Human
Accession BC015807

Human CTH ORF clone (NM_001190463.1) - CDCR051554 from Creative biogene

Species Human

Human CTH ORF Clone (BC015807) - CDCS409203 from Creative biogene

Species Human
Accession P32929

Human CTH ORF clone (BC015807) - CDCB159312 from Creative biogene

Species Human
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