CTH

Gene Symbol CTH
Entrez Gene 1491
Alt Symbol -
Species Human
Gene Type protein-coding
Description cystathionine gamma-lyase
Other Description cystathionase (cystathionine gamma-lyase)|cysteine desulfhydrase|cysteine-protein sulfhydrase|gamma-cystathionase|homoserine deaminase|homoserine dehydratase
Swissprots Q53Y79 E9PDV0 P32929 Q9H4W7 Q53FB3 Q9H4W8 B4E1R2
Accessions EAX06450 EAX06451 P32929 AK223376 BAD97096 AK303946 BAG64874 AK310269 BC015807 AAH15807 BT006882 AAP35528 DB466459 EU832313 ACE87570 EU832398 ACE86883 S52028 AAB24699 S52784 AAB24700 XM_005270509 XP_005270566 XM_011540787 XP_011539089 NM_001190463 NP_001177392 NM_001902 NP_001893 NM_153742 NP_714964
Function Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. {ECO:0000269|PubMed:19019829, ECO:0000269|PubMed:19261609, ECO:0000269|PubMed:22169477}.
Subcellular Location Cytoplasm.
Top Pathways Glycine, serine and threonine metabolism, Cysteine and methionine metabolism, Selenocompound metabolism, Biosynthesis of amino acids

CTH CRISPR/Cas9 KO Plasmid (h) - sc-401134 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTH HDR Plasmid (h) - sc-401134-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTH Double Nickase Plasmid (h) - sc-401134-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTH Double Nickase Plasmid (h2) - sc-401134-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTH CRISPR Activation Plasmid (h) - sc-401134-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTH CRISPR Activation Plasmid (h2) - sc-401134-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTH Lentiviral Activation Particles (h) - sc-401134-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTH Lentiviral Activation Particles (h2) - sc-401134-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTH siRNA (h) - sc-78973 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CTH shRNA Plasmid (h) - sc-78973-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CTH shRNA (h) Lentiviral Particles - sc-78973-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Cystathionase RNAi - H00001491-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU078251 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6730 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6730 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03552 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03552

CTH siRNA (Human) - CRH1055 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Cystathionase RNAi - H00001491-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CTH - MBS8202120 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CTH CRISPR/Cas9 KO Plasmid (h2) - sc-401134-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTH HDR Plasmid (h2) - sc-401134-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTH shRNA Plasmid (Human) - CHH1055 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CTH miRNA 3'UTR clone - MiUTR3H-09371 from Creative biogene

Species Reactivities Human

CTH miRNA 3'UTR clone - MiUTR3H-09372 from Creative biogene

Species Reactivities Human
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