| Gene Symbol |
Sgpp1
|
| Entrez Gene |
81535
|
| Alt Symbol |
AI463453, SPP, SPP1, Spph1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
sphingosine-1-phosphate phosphatase 1
|
| Other Description |
SPPase1|sphingosine-1-phosphatase 1
|
| Swissprots |
Q9JI99
|
| Accessions |
EDL36482 EDL36483 Q9JI99 AF247177 AAF90052 AF415215 AAL07501 AK028125 AK043586 AK149860 BAE29129 AK154116 BAE32385 BC026814 BC037592 AAH37592 NM_030750 NP_109675
|
| Function |
Has enzymatic activity against both sphingosine 1- phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in liver and kidney. {ECO:0000269|PubMed:10859351}.
|
| Top Pathways |
Sphingolipid signaling pathway, Sphingolipid metabolism
|