| Gene Symbol |
Cd63
|
| Entrez Gene |
12512
|
| Alt Symbol |
C75951, ME491, Tspan30
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
CD63 antigen
|
| Other Description |
melanoma 1 antigen
|
| Swissprots |
P41731
|
| Accessions |
EDL24631 P41731 AF159427 AAD43135 AK028220 BAC25821 AK146618 BAE27307 AK150647 BAE29734 AK151702 BAE30625 AK151963 BAE30834 AK152072 BAE30925 AK152372 BAE31162 AK159875 BAE35447 AK163785 BAE37493 AK166373 AK166543 BAE38843 AK166766 BAE39004 AK170344 BAE41734 AK178060 AK178582 AK182243 AK184072 AK184717 AK188607 AK188949 AK208438 AK210314 AK211715 AK216882 BC008108 AAH08108 BC012212 AAH12212 BC083161 AAH83161 BP769648 BY164291 CF355016 CJ210573 CT010179 CAJ18387 D16432 BAA03904 NM_001042580 NP_001036045 NM_001282966 NP_001269895 NM_007653 NP_031679
|
| Function |
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269|PubMed:19075008, ECO:0000269|PubMed:2
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body {ECO:0000250}. Melanosome {ECO:0000250}. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous. Strongly expressed in kidney. Detected in spleen, bone marrow, peripheral blood mononuclear cells and macrophages.
|
| Top Pathways |
Lysosome, Proteoglycans in cancer
|