| Gene Symbol |
CYP24A1
|
| Entrez Gene |
1591
|
| Alt Symbol |
CP24, CYP24, HCAI, P450-CC24
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 24, subfamily A, polypeptide 1
|
| Other Description |
1,25-@dihydroxyvitamin D3 24-hydroxylase|1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial|24-OHase|cytochrome P450 24A1|cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase)|cytochrome P450-CC24|exo-mitochondrial protein|vitamin D 24-hydroxylase|vitamin D(3) 24-hydroxylase
|
| Swissprots |
Q15807 Q07973 Q5I2W7 Q32ML3
|
| Accessions |
AAB03776 EAW75573 Q07973 AI400154 AW022349 AY858838 AAW50795 BC109083 AAI09084 BC109084 AAI09085 BI491491 BM928702 BU662901 CN311231 L13286 AAA62379 N29030 S67623 AAB29308 XM_005260304 XP_005260361 NM_000782 NP_000773 NM_001128915 NP_001122387
|
| Function |
Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.
|
| Subcellular Location |
Mitochondrion.
|
| Top Pathways |
MicroRNAs in cancer, Steroid biosynthesis
|
