| Gene Symbol |
Fbl
|
| Entrez Gene |
292747
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
fibrillarin
|
| Other Description |
histone-glutamine methyltransferase|nucleolar protein 1|rRNA 2'-O-methyltransferase fibrillarin
|
| Swissprots |
Q4KLH8 P22509
|
| Accessions |
EDM07914 EDM07915 P22509 BC099198 AAH99198 FQ230160 FQ231058 NM_001025643 NP_001020814
|
| Function |
S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:2414294}. Note=Fibrillar region of the nucleolus.
|
| Top Pathways |
Ribosome biogenesis in eukaryotes
|