| Gene Symbol | Fbl |
|---|---|
| Entrez Gene | 292747 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | fibrillarin |
| Other Description | histone-glutamine methyltransferase|nucleolar protein 1|rRNA 2'-O-methyltransferase fibrillarin |
| Swissprots | Q4KLH8 P22509 |
| Accessions | EDM07914 EDM07915 P22509 BC099198 AAH99198 FQ230160 FQ231058 NM_001025643 NP_001020814 |
| Function | S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:2414294}. Note=Fibrillar region of the nucleolus. |
| Top Pathways | Ribosome biogenesis in eukaryotes |
CompoZr® Knockout ZFN Kit - CKOZFN53885 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND53885 from Sigma-Aldrich
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FBL siRNA (Rat) - CRR4228 from Cohesion Biosciences
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FBL - MBS8204776 from MyBioSource
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shRNA set against Rat FBL (NM_001025643.1) - SHH292661 from Creative biogene
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shRNA set against Rat Fbl(NM_001025643.1) - SHH050087 from Creative biogene
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FBL shRNA Plasmid (Rat) - CHR4228 from Cohesion Biosciences
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FBL miRNA 3'UTR clone - MiUTR1R-01834 from Creative biogene
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