DDB2

Gene Symbol	DDB2
Entrez Gene	1643
Alt Symbol	DDBB, UV-DDB2
Species	Human
Gene Type	protein-coding
Description	damage-specific DNA binding protein 2, 48kDa
Other Description	DDB p48 subunit|DNA damage-binding protein 2|UV-DDB 2|UV-damaged DNA-binding protein 2|damage-specific DNA-binding protein 2|xeroderma pigmentosum group E protein
Swissprots	Q76E56 Q76E55 Q76E54 Q92466 Q76E57 B2R875
Accessions	AAO25655 EAW67952 EAW67953 EAW67954 EAW67955 EAW67956 EAW67957 EAW67958 EAW67959 Q92466 AA278953 AB107037 BAD12557 AB107038 BAD12558 AB107039 BAD12559 AB107040 BAD12560 AK091640 AK313262 BAG36072 BC000093 AAH00093 BC050455 BT007139 AAP35803 DB053816 DQ890719 ABM81645 HQ447914 ADQ32398 U18300 AAB07897 XR_242780 NM_000107 NP_000098 NM_001300734 NP_001287663
Function	Required for DNA repair. Binds to DDB1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1- CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4- ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA r
Subcellular Location	Nucleus {ECO:0000269|PubMed:10777490, ECO:0000269|PubMed:10777491, ECO:0000269|PubMed:11705987, ECO:0000269|PubMed:12944386, ECO:0000269|PubMed:14751237, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16713579, ECO:0000269|PubMed:17635991, ECO:0000269|PubMed:18593899}. Note=Accumulates at sites of DNA damage following UV irradiation.
Tissue Specificity	Ubiquitously expressed; with highest levels in corneal endothelium and lowest levels in brain. Isoform D1 is highly expressed in brain and heart. Isoform D2, isoform D3 and isoform D4 are weakly expressed. {ECO:0000269|PubMed:14751237}.
Top Pathways	p53 signaling pathway, Ubiquitin mediated proteolysis, Nucleotide excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DDB2 peptide - ab87818 from Abcam Category Peptide

Human DDB2 protein fragment - ab91908 from Abcam Category Protein Source E. coli Species Human

DDB2 Antibody Blocking Peptide - LS-E22030 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human XPE/DDB2 Protein - H00001643-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

XPE/DDB2 Partial Recombinant Protein - H00001643-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human XPE/DDB2 Protein - H00001643-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

DDB2 Blocking Peptide - 33R-4210 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DDB2 - H00001643-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

DDB2 - H00001643-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DDB2 - H00001643-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DDB2 - H00001643-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

DDB2 - H00001643-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DDB2 - H00001643-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DDB2 fusion protein - ag0691 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human DDB2 Protein, His-tagged - DDB2-28309TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Damage Specific DNA Binding Protein 2 (DDB2) - RPA319Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Damage Specific DNA Binding Protein 2 (DDB2) - RPA319Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Damage Specific DNA Binding Protein 2 (DDB2) - RPA319Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human DNA damage-binding protein 2(DDB2) - CSB-YP846067HU CSB-EP846067HU CSB-BP846067HU CSB-MP846067HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

XPE/DDB2 Recombinant Protein Antigen - NBP2-38854PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DDB2 Peptide, Human - M34GP04117H from Creative Peptides Category Peptide Source Synthetic. Species Human

DDB2 Recombinant Protein (OPCD02685) - OPCD02685 from Aviva Systems Biology Category Protein Source E.coli Species Human

DNA damage-binding protein 2 (DDB2), Recombinant Protein - MBS1282455 from MyBioSource Category Protein Prices $1,200.00, $1,200.00, $1,425.00, $1,425.00, $1,945.00, $1,945.00, $2,410.00, $2,410.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

DDB2 peptide - orb72604 from Biorbyt Category Peptide

Recombinant Human DDB2 Protein, GST-tagged - DDB2-057H from Creative Biomart Category Protein Source Wheat Germ Species Human

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