DDB2

Gene Symbol DDB2
Entrez Gene 1643
Alt Symbol DDBB, UV-DDB2
Species Human
Gene Type protein-coding
Description damage-specific DNA binding protein 2, 48kDa
Other Description DDB p48 subunit|DNA damage-binding protein 2|UV-DDB 2|UV-damaged DNA-binding protein 2|damage-specific DNA-binding protein 2|xeroderma pigmentosum group E protein
Swissprots Q76E56 Q76E55 Q76E54 Q92466 Q76E57 B2R875
Accessions AAO25655 EAW67952 EAW67953 EAW67954 EAW67955 EAW67956 EAW67957 EAW67958 EAW67959 Q92466 AA278953 AB107037 BAD12557 AB107038 BAD12558 AB107039 BAD12559 AB107040 BAD12560 AK091640 AK313262 BAG36072 BC000093 AAH00093 BC050455 BT007139 AAP35803 DB053816 DQ890719 ABM81645 HQ447914 ADQ32398 U18300 AAB07897 XR_242780 NM_000107 NP_000098 NM_001300734 NP_001287663
Function Required for DNA repair. Binds to DDB1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1- CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4- ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA r
Subcellular Location Nucleus {ECO:0000269|PubMed:10777490, ECO:0000269|PubMed:10777491, ECO:0000269|PubMed:11705987, ECO:0000269|PubMed:12944386, ECO:0000269|PubMed:14751237, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16713579, ECO:0000269|PubMed:17635991, ECO:0000269|PubMed:18593899}. Note=Accumulates at sites of DNA damage following UV irradiation.
Tissue Specificity Ubiquitously expressed; with highest levels in corneal endothelium and lowest levels in brain. Isoform D1 is highly expressed in brain and heart. Isoform D2, isoform D3 and isoform D4 are weakly expressed. {ECO:0000269|PubMed:14751237}.
Top Pathways p53 signaling pathway, Ubiquitin mediated proteolysis, Nucleotide excision repair

DDB2 CRISPR/Cas9 KO Plasmid (h) - sc-401686 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DDB2 HDR Plasmid (h) - sc-401686-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DDB2 Double Nickase Plasmid (h) - sc-401686-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DDB2 Double Nickase Plasmid (h2) - sc-401686-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DDB2 CRISPR Activation Plasmid (h) - sc-401686-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DDB2 CRISPR Activation Plasmid (h2) - sc-401686-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DDB2 Lentiviral Activation Particles (h) - sc-401686-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DDB2 Lentiviral Activation Particles (h2) - sc-401686-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DDB2 siRNA (h) - sc-37799 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DDB2 shRNA Plasmid (h) - sc-37799-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DDB2 shRNA (h) Lentiviral Particles - sc-37799-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

XPE/DDB2 RNAi - H00001643-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU042481 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7020 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7020 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02911 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02911

DDB2 siRNA (Human) - CRH1157 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DDB2 - MBS8235902 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DDB2(NM_000107.2) - SHG225601 from Creative biogene

Category siRNA
Species Reactivities Human

Human DDB2 siRNA - orb261659 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DDB2 shRNA Plasmid (Human) - CHH1157 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DDB2 miRNA 3'UTR clone - MiUTR1H-02706 from Creative biogene

Species Reactivities Human
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