| Gene Symbol |
FOXD3
|
| Entrez Gene |
27022
|
| Alt Symbol |
AIS1, Genesis, HFH2, VAMAS2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
forkhead box D3
|
| Other Description |
HNF3/FH transcription factor genesis|forkhead box protein D3
|
| Swissprots |
Q9UDD1 Q9UJU5 Q9BYM2
|
| Accessions |
AAF05844 EAX06575 Q9UJU5 AF086235 BC172266 AAI72266 BC172572 AAI72572 L12142 AAK13574 NM_012183 NP_036315
|
| Function |
Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. {ECO:0000269|PubMed:11891324}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. {ECO:0000269|PubMed:8499623}.
|