| Gene Symbol |
PLD1
|
| Entrez Gene |
5337
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase D1, phosphatidylcholine-specific
|
| Other Description |
choline phosphatase 1|phosphatidylcholine-hydrolyzing phospholipase D1|phospholipase D1
|
| Swissprots |
Q13393
|
| Accessions |
EAW78480 Q13393 AB209907 BAD93144 AJ276230 CAB76564 AK026225 AK091897 BC068976 AAH68976 BX648900 DA325526 DA464847 HQ257981 ADR82735 U38545 AAB49031 XM_005247533 XP_005247590 XM_005247534 XP_005247591 XM_011512897 XP_011511199 XM_011512898 XP_011511200 XM_011512899 XP_011511201 XR_924146 NM_001130081 NP_001123553 NM_002662 NP_002653
|
| Function |
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Late endosome membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
|
| Tissue Specificity |
Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine. {ECO:0000269|PubMed:9582313}.
|
| Top Pathways |
Sphingolipid signaling pathway, Choline metabolism in cancer, cAMP signaling pathway, Glutamatergic synapse, Endocytosis
|
![Western Blot: Phospholipase D1 Overexpression Lysate (Adult Normal) [NBL1-14494] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Phospholipase D1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/818_Phospholipase%2520D1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14494-img0002.jpg)