| Gene Symbol | BMPR1B |
|---|---|
| Entrez Gene | 658 |
| Alt Symbol | ALK-6, ALK6, CDw293 |
| Species | Human |
| Gene Type | protein-coding |
| Description | bone morphogenetic protein receptor, type IB |
| Other Description | BMP type-1B receptor|BMPR-1B|activin receptor-like kinase 6|bone morphogenetic protein receptor type-1B|serine/threonine receptor kinase |
| Swissprots | O00238 B4DSV1 B2R953 P78366 |
| Accessions | EAX06060 O00238 AK293008 BAF85697 AK299930 BAG61763 AK313642 BAG36400 AW299723 BC047773 AAH47773 BC069796 AAH69796 BC069803 AAH69803 D89675 BAA19765 U89326 AAC28131 XM_011532201 XP_011530503 XM_011532202 XP_011530504 NM_001203 NP_001194 NM_001256792 NP_001243721 NM_001256793 NP_001243722 NM_001256794 NP_001243723 |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Top Pathways | Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells |