| Gene Symbol |
BMPR1B
|
| Entrez Gene |
658
|
| Alt Symbol |
ALK-6, ALK6, CDw293
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
bone morphogenetic protein receptor, type IB
|
| Other Description |
BMP type-1B receptor|BMPR-1B|activin receptor-like kinase 6|bone morphogenetic protein receptor type-1B|serine/threonine receptor kinase
|
| Swissprots |
O00238 B4DSV1 B2R953 P78366
|
| Accessions |
EAX06060 O00238 AK293008 BAF85697 AK299930 BAG61763 AK313642 BAG36400 AW299723 BC047773 AAH47773 BC069796 AAH69796 BC069803 AAH69803 D89675 BAA19765 U89326 AAC28131 XM_011532201 XP_011530503 XM_011532202 XP_011530504 NM_001203 NP_001194 NM_001256792 NP_001243721 NM_001256793 NP_001243722 NM_001256794 NP_001243723
|
| Function |
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells
|
![Western Blot: BMPR1B Overexpression Lysate (Adult Normal) [NBP2-08226] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for BMPR1B.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/14432_BMPR1B%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-08226-img0001.jpg)