| Gene Symbol |
RERG
|
| Entrez Gene |
85004
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAS-like, estrogen-regulated, growth inhibitor
|
| Other Description |
ras-related and estrogen-regulated growth inhibitor
|
| Swissprots |
B4DI02 Q96A58 B2R9R0
|
| Accessions |
EAW96345 EAW96346 Q96A58 AF339750 AAK98530 AI125943 AK295343 BAG58314 AK311016 AK313881 BAG36607 BC007997 AAH07997 DC331754 DQ893192 ABM84118 HQ447141 ADQ31628 XM_011520870 XP_011519172 NM_001190726 NP_001177655 NM_032918 NP_116307
|
| Function |
Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential. {ECO:0000269|PubMed:11533059}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11533059}.
|
| Tissue Specificity |
Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor- positive breast-derived cell lines, but not in estrogen receptor- negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis. {ECO:0000269|PubMed:11533059}.
|