Gene Symbol | RERG |
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Entrez Gene | 85004 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | RAS-like, estrogen-regulated, growth inhibitor |
Other Description | ras-related and estrogen-regulated growth inhibitor |
Swissprots | B4DI02 Q96A58 B2R9R0 |
Accessions | EAW96345 EAW96346 Q96A58 AF339750 AAK98530 AI125943 AK295343 BAG58314 AK311016 AK313881 BAG36607 BC007997 AAH07997 DC331754 DQ893192 ABM84118 HQ447141 ADQ31628 XM_011520870 XP_011519172 NM_001190726 NP_001177655 NM_032918 NP_116307 |
Function | Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential. {ECO:0000269|PubMed:11533059}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11533059}. |
Tissue Specificity | Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor- positive breast-derived cell lines, but not in estrogen receptor- negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis. {ECO:0000269|PubMed:11533059}. |
RERG CRISPR/Cas9 KO Plasmid (h) - sc-410479 from Santa Cruz Biotechnology
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RERG HDR Plasmid (h) - sc-410479-HDR from Santa Cruz Biotechnology
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RERG Double Nickase Plasmid (h) - sc-410479-NIC from Santa Cruz Biotechnology
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RERG Double Nickase Plasmid (h2) - sc-410479-NIC-2 from Santa Cruz Biotechnology
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RERG CRISPR Activation Plasmid (h) - sc-410479-ACT from Santa Cruz Biotechnology
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RERG CRISPR Activation Plasmid (h2) - sc-410479-ACT-2 from Santa Cruz Biotechnology
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RERG Lentiviral Activation Particles (h) - sc-410479-LAC from Santa Cruz Biotechnology
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RERG Lentiviral Activation Particles (h2) - sc-410479-LAC-2 from Santa Cruz Biotechnology
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RERG siRNA (h) - sc-96069 from Santa Cruz Biotechnology
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RERG shRNA Plasmid (h) - sc-96069-SH from Santa Cruz Biotechnology
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RERG shRNA (h) Lentiviral Particles - sc-96069-V from Santa Cruz Biotechnology
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RERG RNAi - H00085004-R01 from Novus Biologicals
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MISSION® esiRNA - EHU153991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18150 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18150 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09059 from Sigma-Aldrich
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RERG siRNA (Human) - CRJ3751 from Cohesion Biosciences
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RERG - MBS8212374 from MyBioSource
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shRNA set against Human RERG (NM_032918.2) - SHH391996 from Creative biogene
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RERG shRNA Plasmid (Human) - CHJ3751 from Cohesion Biosciences
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RERG miRNA 3'UTR clone - MiUTR3H-12537 from Creative biogene
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