| Gene Symbol |
Plat
|
| Entrez Gene |
25692
|
| Alt Symbol |
PATISS, tPA
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
plasminogen activator, tissue
|
| Other Description |
t-PA|t-plasminogen activator|tissue plasminogen activator|tissue-type plasminogen activator
|
| Swissprots |
P19637
|
| Accessions |
AAA42261 EDM09013 EDM09014 P19637 BC061565 AAH61565 M23697 AAA41812 XM_006253347 XP_006253409 XM_008771348 XP_008769570 NM_013151 NP_037283
|
| Function |
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.
|
| Subcellular Location |
Secreted, extracellular space.
|
| Top Pathways |
Complement and coagulation cascades, Transcriptional misregulation in cancer
|