| Gene Symbol | Plat |
|---|---|
| Entrez Gene | 25692 |
| Alt Symbol | PATISS, tPA |
| Species | Rat |
| Gene Type | protein-coding |
| Description | plasminogen activator, tissue |
| Other Description | t-PA|t-plasminogen activator|tissue plasminogen activator|tissue-type plasminogen activator |
| Swissprots | P19637 |
| Accessions | AAA42261 EDM09013 EDM09014 P19637 BC061565 AAH61565 M23697 AAA41812 XM_006253347 XP_006253409 XM_008771348 XP_008769570 NM_013151 NP_037283 |
| Function | Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. |
| Subcellular Location | Secreted, extracellular space. |
| Top Pathways | Complement and coagulation cascades, Transcriptional misregulation in cancer |
tPA siRNA (r) - sc-45948 from Santa Cruz Biotechnology
|
||||||||
tPA shRNA Plasmid (r) - sc-45948-SH from Santa Cruz Biotechnology
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN60195 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND60195 from Sigma-Aldrich
|
||||||||
PLAT siRNA (Rat) - CRR0880 from Cohesion Biosciences
|
||||||||
shRNA set against Rat PLAT (NM_013151.2) - SHH377045 from Creative biogene
|
||||||||
shRNA set against Rat Plat(NM_013151.2) - SHR119918 from Creative biogene
|
||||||||
Rat PLAT siRNA - orb295729 from Biorbyt
|
||||||||
PLAT shRNA Plasmid (Rat) - CHR0880 from Cohesion Biosciences
|
||||||||
PLAT miRNA 3'UTR clone - MiUTR1R-05888 from Creative biogene
|