| Gene Symbol |
ALOX12B
|
| Entrez Gene |
242
|
| Alt Symbol |
12R-LOX, ARCI2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
arachidonate 12-lipoxygenase, 12R type
|
| Other Description |
12R-lipoxygenase|arachidonate 12-lipoxygenase, 12R-type|epidermis-type lipoxygenase 12
|
| Swissprots |
O75342
|
| Accessions |
CAC34520 EAW90095 O75342 AF038461 AAC39770 AF059250 AAC79680 BC041058 AAH41058 NM_001139 NP_001130
|
| Function |
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)- hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins. {ECO:0000269|PubMed:21558561, ECO:0000269|PubMed:22441738, ECO:0000269|PubMed:9618483}.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00726}.
|
| Tissue Specificity |
Expressed in B-cells, hair follicles, foreskin keratinocytes and adult skin. Also expressed in psoriatic tissue. {ECO:0000269|PubMed:9618483}.
|
| Top Pathways |
Arachidonic acid metabolism
|