| Gene Symbol |
Rgs9bp
|
| Entrez Gene |
243923
|
| Alt Symbol |
R9AP, Rgs9-1bp
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
regulator of G-protein signalling 9 binding protein
|
| Other Description |
RGS9 anchor protein|RGS9-1 anchor|RGS9-anchoring protein|regulator of G-protein signaling 9-binding protein
|
| Swissprots |
Q148R9 Q8K462
|
| Accessions |
Q148R9 AF483907 AAM76160 AK044285 AY229888 AAP55847 BC118006 AAI18007 CO046102 NM_145840 NP_665839
|
| Function |
Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation. {ECO:0000269|PubMed:12560335, ECO:0000269|PubMed:14625292, ECO:0000269|PubMed:16908407, ECO:0000269|PubMed:16939221}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:12119397}; Single-pass type IV membrane protein {ECO:0000269|PubMed:12119397}.
|
| Tissue Specificity |
Predominantly expressed in photoreceptors of the retina. Weakly expressed in other areas of the central nervous system. {ECO:0000269|PubMed:12119397, ECO:0000269|PubMed:14664818}.
|