Gene Symbol | Rgs9bp |
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Entrez Gene | 243923 |
Alt Symbol | R9AP, Rgs9-1bp |
Species | Mouse |
Gene Type | protein-coding |
Description | regulator of G-protein signalling 9 binding protein |
Other Description | RGS9 anchor protein|RGS9-1 anchor|RGS9-anchoring protein|regulator of G-protein signaling 9-binding protein |
Swissprots | Q148R9 Q8K462 |
Accessions | Q148R9 AF483907 AAM76160 AK044285 AY229888 AAP55847 BC118006 AAI18007 CO046102 NM_145840 NP_665839 |
Function | Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation. {ECO:0000269|PubMed:12560335, ECO:0000269|PubMed:14625292, ECO:0000269|PubMed:16908407, ECO:0000269|PubMed:16939221}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:12119397}; Single-pass type IV membrane protein {ECO:0000269|PubMed:12119397}. |
Tissue Specificity | Predominantly expressed in photoreceptors of the retina. Weakly expressed in other areas of the central nervous system. {ECO:0000269|PubMed:12119397, ECO:0000269|PubMed:14664818}. |
R9AP CRISPR/Cas9 KO Plasmid (m) - sc-434022 from Santa Cruz Biotechnology
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R9AP HDR Plasmid (m) - sc-434022-HDR from Santa Cruz Biotechnology
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R9AP Double Nickase Plasmid (m) - sc-434022-NIC from Santa Cruz Biotechnology
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R9AP Double Nickase Plasmid (m2) - sc-434022-NIC-2 from Santa Cruz Biotechnology
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R9AP CRISPR Activation Plasmid (m) - sc-434022-ACT from Santa Cruz Biotechnology
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R9AP CRISPR Activation Plasmid (m2) - sc-434022-ACT-2 from Santa Cruz Biotechnology
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R9AP Lentiviral Activation Particles (m) - sc-434022-LAC from Santa Cruz Biotechnology
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R9AP Lentiviral Activation Particles (m2) - sc-434022-LAC-2 from Santa Cruz Biotechnology
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R9AP siRNA (m) - sc-152624 from Santa Cruz Biotechnology
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R9AP shRNA Plasmid (m) - sc-152624-SH from Santa Cruz Biotechnology
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R9AP shRNA (m) Lentiviral Particles - sc-152624-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU038361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN40167 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND40167 from Sigma-Aldrich
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RGS9BP siRNA (Mouse) - CRN3692 from Cohesion Biosciences
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RGS9BP - MBS8203661 from MyBioSource
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shRNA set against Mouse Rgs9bp(NM_145840.3) - SHR179814 from Creative biogene
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RGS9BP shRNA Plasmid (Mouse) - CHN3692 from Cohesion Biosciences
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RGS9BP miRNA 3'UTR clone - MiUTR1M-10082 from Creative biogene
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