| Gene Symbol |
Nppb
|
| Entrez Gene |
25105
|
| Alt Symbol |
BNP, Bnf
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
natriuretic peptide B
|
| Other Description |
Brain natriuretic factor|brain natriuretic peptide|gamma-brain natriuretic peptide|iso-ANP|natriuretic peptide precursor B|natriuretic peptide precursor type B|natriuretic peptides B
|
| Swissprots |
P13205
|
| Accessions |
AAA21648 AAA41455 AAA41456 EDL81087 P13205 FQ228997 M25297 AAA57269 XM_006239376 XP_006239438 NM_031545 NP_113733
|
| Function |
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Brain and also in atria, but at much lower levels than ANP.
|
| Top Pathways |
cGMP-PKG signaling pathway
|