PAK2

Gene Symbol	PAK2
Entrez Gene	5062
Alt Symbol	PAK65, PAKgamma
Species	Human
Gene Type	protein-coding
Description	p21 protein (Cdc42/Rac)-activated kinase 2
Other Description	PAK-2|S6/H4 kinase|gamma-PAK|p21 (CDKN1A)-activated kinase 2|p21-activated kinase 2|p58|serine/threonine-protein kinase PAK 2
Swissprots	Q6ISC3 Q13177 Q13154
Accessions	AFG72980 Q13177 AI140979 AK291339 BAF84028 BC031667 BC046197 BC063539 BC069613 AAH69613 BG572555 CA445078 DB164364 DQ786200 U24153 AAA65442 U25975 AAA75468 XM_011512870 XP_011511172 NM_002577 NP_002568
Function	Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF- induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the o
Subcellular Location	Serine/threonine-protein kinase PAK 2: Cytoplasm. Note=MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane.
Tissue Specificity	Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen.
Top Pathways	Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PAK2 protein fragment - ab95310 from Abcam Category Protein Prices $761.00 Sizes 10 µg Source E. coli Species Human

Human PAK2 full length protein - ab125597 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human PAK2 peptide - ab51559 from Abcam Category Peptide Species Human

PAK2-Antibody-N-term-Blocking-Peptide - BP7927a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PAK2 - H00005062-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PAK2 - H00005062-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PAK2 - P4741 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

PAK2 - P5383 from Acris Antibodies Category Protein Prices $670.00 Sizes 10 µg Species Human

PAK2 - P5789 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

PAK2 Control Peptide - AP30641CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

PAK2 Control Peptide - AP30642CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

PAK2 Peptide - 3885P from ProSci Category Peptide Species Human

PAK2 Peptide - 3887P from ProSci Category Peptide Species Human

Recombinant Human P21 Protein (Cdc42/Rac)-Activated Kinase 2 - PAK2-521H from Creative Biomart Category Protein Source E.Coli.

Recombinant Human PAK2, GST-His - PAK2-721H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cells.

Recombinant Human PAK2 - PAK2-30670TH from Creative Biomart Category Protein Source E. coli

Recombinant Human p21 Protein (Cdc42/Rac)-Activated Kinase 2, GST-tagged - PAK2-1282H from Creative Biomart Category Protein Source Insect cells Species Human

Recombinant p21 Protein Activated Kinase 2 (PAK2) - RPH468Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

PAK2 Protein, active, 10 µg - 14-481 from EMD Millipore Category Protein Prices $401.00 Sizes 10 µg also available in 250 µg size --call for pricing and availability and reference catalog numbe Source Expressed in E. coli

PAK2 Protein, active, 250 µg - 14-481M from EMD Millipore Category Protein Prices $2,544.00 Sizes 250 µg also available in 10 μg size . (cat#14-481) and in bulk (cat# 14-481-K) Source Expressed in E. coli

PAK2 (pS20) Blocking Peptide - CBP1849 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Rabbit

PAK2 (R186) Peptide - BS3751P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-PAK2 (S20) Peptide - BS4857P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant p21 Protein Activated Kinase 2 (PAK2) - RPH468Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Serine/threonine-protein kinase PAK 2(PAK2) - CSB-YP622641HU CSB-EP622641HU CSB-BP622641HU CSB-MP622641HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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