| Gene Symbol |
CHRNA1
|
| Entrez Gene |
1134
|
| Alt Symbol |
ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cholinergic receptor, nicotinic, alpha 1 (muscle)
|
| Other Description |
acetylcholine receptor subunit alpha|acetylcholine receptor, nicotinic, alpha 1 (muscle)|cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)|muscle nicotinic acetylcholine receptor|nicotinic acetylcholine receptor alpha subunit|nicotinic cholinergic receptor alpha 1
|
| Swissprots |
D3DPE8 B4DRV6 P02708
|
| Accessions |
AAY14687 CAA26344 CAA34960 CAA49705 EAX11124 EAX11125 EAX11126 EAX11127 EAX11128 P02708 AK291338 BAF84027 AK299445 BAG61418 AK315312 BAG37716 BC006314 BC043196 BG828551 CD013889 DQ323657 ABD27888 DQ323658 ABD27889 S77094 AAD14247 Y00762 CAA68731 NM_000079 NP_000070 NM_001039523 NP_001034612
|
| Function |
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
|
| Subcellular Location |
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|