POLR2J

Gene Symbol POLR2J
Entrez Gene 5439
Alt Symbol POLR2J1, RPB11, RPB11A, RPB11m, hRPB14
Species Human
Gene Type protein-coding
Description polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
Other Description DNA-directed RNA polymerase II subunit J-1|DNA-directed RNA polymerase II subunit RPB11-a|RNA polymerase II 13.3 kDa subunit|RNA polymerase II subunit B11-a
Swissprots O43375 A5D6V8 P52435
Accessions CAC18368 P52435 AK290515 BAF83204 BC024165 AAH24165 BC040116 BC065711 AAH65711 BC139902 AAI39903 BC141830 AAI41831 BM545237 BM791979 DQ893151 ABM84077 DQ896446 ABM87445 L37127 AAD05361 X82385 CAA57785 X98433 CAA67075 XM_005250452 XP_005250509 NM_006234 NP_006225
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:9852112}.
Tissue Specificity Ubiquitously expressed. High expression was found in heart and skeletal muscle. {ECO:0000269|PubMed:11747469}.
Top Pathways Huntington's disease, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism