CYBB

Gene Symbol CYBB
Entrez Gene 1536
Alt Symbol AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, IMD34, NOX2, p91-PHOX
Species Human
Gene Type protein-coding
Description cytochrome b-245, beta polypeptide
Other Description CGD91-phox|NADPH oxidase 2|cytochrome b(558) subunit beta|cytochrome b-245 heavy chain|cytochrome b558 subunit beta|heme-binding membrane glycoprotein gp91phox|neutrophil cytochrome b 91 kDa polypeptide|p22 phagocyte B-cytochrome|superoxide-generating NADPH oxidase heavy chain subunit
Swissprots P04839 A8K138 Q2PP16
Accessions AAL76082 ABC40728 ABY87073 ADQ73898 BAA34183 CAA29327 EAW59453 P04839 AK289753 BAF82442 AK301476 BAG62993 AK301491 BAG63002 AK304033 BAG64947 AK312929 BC032720 AAH32720 DA995835 DQ890878 ABM81804 DQ894032 ABM84958 S67289 AAB29151 X04011 CAA27635 XM_011543890 XP_011542192 NM_000397 NP_000388
Function Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Detected in neutrophils (at protein level). {ECO:0000269|PubMed:19028840}.
Top Pathways Leukocyte transendothelial migration, Phagosome, Osteoclast differentiation

cytochrome b558-β (C-18) - sc-27637 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

gp91-phox (54.1) - sc-130543 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
gp91-phox (54.1): sc-130543. Western blot analysis of gp91-phox expression in A-10 whole cell lysate.

gp91-phox (C-15) - sc-5827 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
gp91-phox (C-15): sc-5827. Western blot analysis of gp91-phox expression in A-10 whole cell lysate.

gp91-phox (CL5) - sc-130549 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

gp91-phox (E-19) - sc-27635 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
gp91-phox (E-19): sc-27635. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cervix tissue showing cytoplasmic staining of squamous epithelial cells.

gp91-phox (G-1) - sc-74514 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
gp91-phox (G-1): sc-74514. Western blot analysis of gp91-phox expression in COLO 320DM (A), Hep G2 (B), OV-90 (C) and A-10 (D) whole cell lysates.

gp91-phox (K-15) - sc-5826 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
gp91-phox (K-15): sc-5826. Immunoperoxidase staining of formalin fixed, paraffin-embedded human stomach tissue showing cytoplasmic staining of glandular cells.

gp91-phox (H-60) - sc-20782 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
gp91-phox (H-60): sc-20782. Western blot analysis of gp91-phox expression in mouse lymphnode (A) and rat pituitary (B) tissue extracts.

gp91-phox (NL7) - sc-130548 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

gp91-phox (V-13) - sc-27636 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-NOX2/gp91phox antibody - ab31092 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-NOX2/gp91phox antibody (ab31092) at 1 µg/ml + NOX2 Human Partial Recombinant Protein at 0.1 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-NOX2/gp91phox antibody - ab131083 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NOX2/gp91phox antibody (ab131083) at 0.5 µg/mlLane 1 : HeLa cell lysateLane 2 : Jurkat cell lysateLane 3 : MCF7 cell lysateLane 4 : SMMC cell lysate

Anti-NOX2/gp91phox antibody - ab180642 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-NOX2/gp91phox antibody (ab180642) at 1/500 dilution + MCF7 cell line extract

Anti-NOX2/gp91phox antibody - ab106940 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-NOX2/gp91phox antibody (ab106940) at 0.03 µg/ml + Peripheral Blood Mononucleocytes lysate at 35 µgdeveloped using the ECL technique

Anti-NOX2/gp91phox antibody - ab111175 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab111175, at 5 µg/ml, staining NOX2/gp91phox in formalin fixed, paraffin embedded Human placenta tissue by Immunohistochemistry, followed by biotinylated secondary antibody, alkaline phosphatase streptavidin and chromogen.

Anti-NOX2/gp91phox antibody [48] - ab139371 from Abcam

Prices $378.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone 48
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labelling NOX2/gp91phox with ab139371 at 10 µg/ml.

Anti-NOX2/gp91phox antibody [54.1] - ab80897 from Abcam

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 54.1
All lanes : Anti-NOX2/gp91phox antibody [54.1] (ab80897) at 1 µg/mlLane 1 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 3 : Lymph node (Human) Tissue Lysate - adult normal tissue (ab29871)Lane 4 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Mouse IgG H&L (HRP) preadsorbed (ab97040) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-NOX2/gp91phox antibody [54.1] (HRP) - ab187934 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 54.1

Anti-NOX2/gp91phox antibody [EPR6991] - ab129068 from Abcam

Prices $401.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6991
All lanes : Anti-NOX2/gp91phox antibody [EPR6991] (ab129068) at 1/1000 dilution (unpurified)Lane 1 : MCF-7 cell lysateLane 2 : HepG2 cell lysateLane 3 : Caco-2 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP-conjugated goat anti-rabbit IgG at 1/2000 dilution

Anti-NOX2 / gp91phox Antibody (aa453-502) - LS-C199872 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of gp91-phox antibody in extracts from HT29 cells.

Anti-NOX2 / gp91phox Antibody - LS-C192744 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts of MCF7 cell lines, using CYBB antibody.

Anti-NOX2 / gp91phox Antibody (aa512-561) - LS-C205905 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NOX2 / gp91phox / gp91 phox antibody Western Blot of 721_B. Antibody dilution: 1 ug/ml.

Anti-NOX2 / gp91phox Antibody (Internal, clone EPR6991) IHC-plus™ - LS-B8979 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6991
Anti-NOX2 / gp91phox antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-NOX2 / gp91phox Antibody - LS-C335167 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using CYBB antibody.

Anti-NOX2 / gp91phox Antibody (clone 48) IHC-plus™ - LS-B6247 from LifeSpan Bioscience

Prices $395.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone 48
Anti-NOX2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6247 concentration 10 ug/ml.
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