CYBB

Gene Symbol	CYBB
Entrez Gene	1536
Alt Symbol	AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, IMD34, NOX2, p91-PHOX
Species	Human
Gene Type	protein-coding
Description	cytochrome b-245, beta polypeptide
Other Description	CGD91-phox|NADPH oxidase 2|cytochrome b(558) subunit beta|cytochrome b-245 heavy chain|cytochrome b558 subunit beta|heme-binding membrane glycoprotein gp91phox|neutrophil cytochrome b 91 kDa polypeptide|p22 phagocyte B-cytochrome|superoxide-generating NADPH oxidase heavy chain subunit
Swissprots	P04839 A8K138 Q2PP16
Accessions	AAL76082 ABC40728 ABY87073 ADQ73898 BAA34183 CAA29327 EAW59453 P04839 AK289753 BAF82442 AK301476 BAG62993 AK301491 BAG63002 AK304033 BAG64947 AK312929 BC032720 AAH32720 DA995835 DQ890878 ABM81804 DQ894032 ABM84958 S67289 AAB29151 X04011 CAA27635 XM_011543890 XP_011542192 NM_000397 NP_000388
Function	Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Detected in neutrophils (at protein level). {ECO:0000269|PubMed:19028840}.
Top Pathways	Leukocyte transendothelial migration, Phagosome, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NOX2/gp91phox peptide - ab111671 from Abcam Category Peptide Species Human

Human NOX2/gp91phox peptide - ab32458 from Abcam Category Peptide

Human NOX2/gp91phox protein fragment - ab114183 from Abcam Category Protein Source Wheat germ Species Human

NOX2 / gp91phox Antibody Blocking Peptide - LS-E26857 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CYBB/NOX2 Protein - H00001536-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NOX2 / gp91phox blocking peptide - GTX88404-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog

Human CYBB protein - orb246219 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

NOX2/gp91phox Peptide - AC21-1691-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Cytochrome b-245 heavy chain - H00001536-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Cytochrome b-245 heavy chain - H00001536-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CYBB Peptide - 42-007P from ProSci Category Peptide Species Human

NOX2 Peptide - 7923P from ProSci Category Peptide Species Human

CYBB fusion protein - Ag5536 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

CYBB fusion protein - ag4402 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CYBB - CYBB-30450TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human CYBB, His-tagged - CYBB-11752H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Cytochrome b-245 Beta Polypeptide (CYBb) - RPD308Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

gp91 phox Blocking Peptide - CBP1306 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Pig, Rabbit, Sheep

gp91-phox (I502) Peptide - BS9035P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Cytochrome b-245 Beta Polypeptide (CYBb) - RPD308Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant human Cytochrome b-245 heavy chain - CSB-YP006325HU CSB-BP006325HU CSB-MP006325HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Cytochrome b-245 heavy chain - CSB-EP006325HU from Cusabio Category Protein Source E.coli Species Human

CYBB/GP91-PHOX, Peptide - MBS425638 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog

CYBB/NOX2 Recombinant Protein Antigen - NBP2-38642PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

gp91 phox Blocking Peptide - abx061174 from Abbexa Category Peptide Species Human

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