Gene Symbol | ANGPT2 |
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Entrez Gene | 607616 |
Alt Symbol | ANG-2 |
Species | Dog |
Gene Type | protein-coding |
Description | angiopoietin 2 |
Other Description | angiopoietin-2 |
Swissprots | A0A8J8 |
Accessions | A0A8J8 AB256019 BAE93229 XM_005629928 XP_005629985 XM_005629929 XP_005629986 NM_001048126 NP_001041591 |
Function | Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted {ECO:0000250}. |
Top Pathways | PI3K-Akt signaling pathway, Rap1 signaling pathway |
Angiopoietin 2, Canine, ELISA Kit - E08A0503 from ARP American Research Products
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Angiopoietin-2, ANGPT2, Dog, ELISA Kit - E0009d from ARP American Research Products
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angiopoietin 2, ELISA Kit - MBS9332290 from MyBioSource
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Canine Angiopoietin 2 ELISA - E08A0503 from BlueGene Biotech
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Dog Angiopoietin-2 ELISA Kit - EKE54254 from Biomatik
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Canine ANGPT2 ELISA Kit - E075233 from Biobool
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ANGPT2 ELISA Kit (Dog) (OKEH03785) - OKEH03785 from Aviva Systems Biology
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Dog Angiopoietin-2 ELISA Kit - EK1023 from Signalway Antibody
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Angiopoietin-2, ELISA Kit - MBS288641 from MyBioSource
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