| Gene Symbol | MNAT1 |
|---|---|
| Entrez Gene | 4331 |
| Alt Symbol | CAP35, MAT1, RNF66, TFB3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | MNAT CDK-activating kinase assembly factor 1 |
| Other Description | CDK-activating kinase assembly factor MAT1|CDK7/cyclin-H assembly factor|RING finger protein 66|RING finger protein MAT1|cyclin G1 interacting protein|cyclin-G1-interacting protein|menage a trois 1 (CAK assembly factor)|menage a trois homolog 1, cyclin H assembly factor |
| Swissprots | Q15817 G3V1U8 Q6ICQ7 P51948 |
| Accessions | AAN47195 EAW80787 EAW80788 EAW80789 EAW80790 EAW80791 P51948 AA053721 AK308701 BC000820 AAH00820 BU620200 CD701743 CR450336 CAG29332 HQ447795 ADQ32279 U61835 AAB05248 X87843 CAA61112 X92669 CAA63356 XM_005267687 XP_005267744 XM_005267688 XP_005267745 XM_011536795 XP_011535097 NM_001177963 NP_001171434 NM_002431 NP_002422 |
| Function | Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269|PubMed:10024882}. |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes. |
| Top Pathways | Nucleotide excision repair, Basal transcription factors |