MNAT1

Gene Symbol MNAT1
Entrez Gene 4331
Alt Symbol CAP35, MAT1, RNF66, TFB3
Species Human
Gene Type protein-coding
Description MNAT CDK-activating kinase assembly factor 1
Other Description CDK-activating kinase assembly factor MAT1|CDK7/cyclin-H assembly factor|RING finger protein 66|RING finger protein MAT1|cyclin G1 interacting protein|cyclin-G1-interacting protein|menage a trois 1 (CAK assembly factor)|menage a trois homolog 1, cyclin H assembly factor
Swissprots Q15817 G3V1U8 Q6ICQ7 P51948
Accessions AAN47195 EAW80787 EAW80788 EAW80789 EAW80790 EAW80791 P51948 AA053721 AK308701 BC000820 AAH00820 BU620200 CD701743 CR450336 CAG29332 HQ447795 ADQ32279 U61835 AAB05248 X87843 CAA61112 X92669 CAA63356 XM_005267687 XP_005267744 XM_005267688 XP_005267745 XM_011536795 XP_011535097 NM_001177963 NP_001171434 NM_002431 NP_002422
Function Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269|PubMed:10024882}.
Subcellular Location Nucleus.
Tissue Specificity Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes.
Top Pathways Nucleotide excision repair, Basal transcription factors

MNAT1-Over-expression-Lysate - LY12889a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag MNAT1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MNAT1 gene

MNAT1 293 Cell Lysate - 409062 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg
Species Xenopus

MNAT1 Overexpression Lysate (Native) - NBL1-13164 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: MNAT1 Overexpression Lysate (Adult Normal) [NBL1-13164] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MNAT1.

MNAT1 Over-expression Lysate Product - GWB-88091F from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human MNAT1 Knockdown Stable Cell Line - CSC-DC009617 from Creative biogene

Category Cell Line
Species Human
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