ACOX1

Gene Symbol ACOX1
Entrez Gene 51
Alt Symbol ACOX, PALMCOX, SCOX
Species Human
Gene Type protein-coding
Description acyl-CoA oxidase 1, palmitoyl
Other Description AOX|acyl-CoA oxidase, straight-chain|acyl-Coenzyme A oxidase 1, palmitoyl|palmitoyl-CoA oxidase|peroxisomal acyl-coenzyme A oxidase 1|peroxisomal fatty acyl-CoA oxidase|straight-chain acyl-CoA oxidase
Swissprots Q9UD31 Q15068 Q15101 A8KAA0 A8K6X8 Q16131 Q7Z3W5 B4DK61 Q12863 F5GYQ8 Q15067
Accessions AAA19113 AAA19114 CBF60587 CBF65740 CBF73135 CBU85830 CBU90611 CBU96027 EAW89349 EAW89350 EAW89351 EAW89352 Q15067 AK095501 AK225897 AK291793 BAF84482 AK292965 BAF85654 AK296409 BAG59073 AK300447 BAG62169 AK308218 AM393156 CAL38034 BC008767 AAH08767 BC010425 AAH10425 BQ943492 BX537380 CAD97622 DC297086 S69189 AAB30019 U07866 AAA18595 X71440 CAA50574 XM_011524868 XP_011523170 XM_011524869 XP_011523171 NM_001185039 NP_001171968 NM_004035 NP_004026 NM_007292 NP_009223
Function Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA. {ECO:0000269|PubMed:17458872, ECO:0000269|PubMed:17603022}.
Subcellular Location Peroxisome.
Tissue Specificity Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart. {ECO:0000269|PubMed:17603022, ECO:0000269|PubMed:20195242}.
Top Pathways PPAR signaling pathway, Peroxisome, cAMP signaling pathway, alpha-Linolenic acid metabolism, Fatty acid degradation

ACOX1 (H-140) - sc-98499 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ACOX1 (H-140): sc-98499. Immunoperoxidase staining of formalin fixed, paraffin-embedded human brain tissue showing cytoplasmic staining of neuronal and glial cells.

ACOX1 (A-23) - sc-130678 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
ACOX1 (A-23): sc-130678. Western blot analysis of ACOX1 expression in non-transfected (A) and human ACOX1 transfected (B) 293 whole cell lysates.

ACOX1 (E-14) - sc-107375 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ACOX1 (G-13) - sc-107376 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACOX1 (G-13): sc-107376. Western blot analysis of ACOX1 expression in MCF7 (A), K-562 (B) and Hep G2 (C) whole cell lysates.

Anti-ACOX1 antibody - ab128549 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab128549, at 1/100 dilution, staining ACOX1 in Formalin-fixed paraffin-embedded Human breast carcinoma tissue Immunohistochemistry.

Anti-ACOX1 antibody - ab37740 from Abcam

Prices $376.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Anti-ACOX1 antibody (ab37740) at 1/2000 dilution + ACOX1 iso a fusion protein at 0.5 µgSecondaryGoat anti-IgY-HRP at 1/1000 dilution

Anti-ACOX1 antibody - Aminoterminal end - ab59964 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ACOX1 antibody - Aminoterminal end (ab59964) at 1/1000 dilution + Mouse liver lysate

Anti-ACOX1 antibody - C-terminal - ab71483 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ACOX1 antibody - C-terminal (ab71483) at 1/50 dilutionLane 1 : Non-transfected 293 cell lysatesLane 2 : ACOX1 (clone RB04652) transfected 293 cell lysatesLysates/proteins at 2 µg per lane.

Anti-ACOX1 / ACOX Antibody IHC-plus™ - LS-B11320 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Anti-ACOX1 / ACOX antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11320 dilution 1:50.

Anti-ACOX1 / ACOX Antibody (clone 153CT43.1.1, FITC) - LS-C250074 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone 153CT43.1.1

Anti-ACOX1 / ACOX Antibody (Internal) - LS-C155308 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: HepG2 7.5% SDS PAGE ACOX1 antibody diluted at 1:500

Anti-ACOX1 / ACOX Antibody (clone 153CT43.1.1, Azide-free, HRP) - LS-C250075 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone 153CT43.1.1

Anti-ACOX1 / ACOX Antibody (clone 153CT43.1.1, PE) - LS-C250076 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone 153CT43.1.1

Anti-ACOX1 / ACOX Antibody (C-Terminus, AP) - LS-C274832 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACOX1 / ACOX Antibody (C-Terminus, Biotin) - LS-C274833 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACOX1 / ACOX Antibody (C-Terminus, FITC) - LS-C274836 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACOX1 / ACOX Antibody (C-Terminus, Azide-free, HRP) - LS-C274835 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACOX1 / ACOX Antibody (N-Terminus, AP) - LS-C274837 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACOX1 / ACOX Antibody (C-Terminus, APC) - LS-C274834 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACOX1 / ACOX Antibody (N-Terminus, APC) - LS-C274838 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACOX1 / ACOX Antibody (C-Terminus, PE) - LS-C274839 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACOX1 / ACOX Antibody (N-Terminus, Biotin) - LS-C274840 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACOX1 / ACOX Antibody (N-Terminus, FITC) - LS-C274841 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACOX1 / ACOX Antibody (N-Terminus, Azide-free, HRP) - LS-C274842 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACOX1 / ACOX Antibody (aa7-37) - LS-C98495 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ACOX1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human bladder carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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