ACOX1

Gene Symbol ACOX1
Entrez Gene 51
Alt Symbol ACOX, PALMCOX, SCOX
Species Human
Gene Type protein-coding
Description acyl-CoA oxidase 1, palmitoyl
Other Description AOX|acyl-CoA oxidase, straight-chain|acyl-Coenzyme A oxidase 1, palmitoyl|palmitoyl-CoA oxidase|peroxisomal acyl-coenzyme A oxidase 1|peroxisomal fatty acyl-CoA oxidase|straight-chain acyl-CoA oxidase
Swissprots Q9UD31 Q15068 Q15101 A8KAA0 A8K6X8 Q16131 Q7Z3W5 B4DK61 Q12863 F5GYQ8 Q15067
Accessions AAA19113 AAA19114 CBF60587 CBF65740 CBF73135 CBU85830 CBU90611 CBU96027 EAW89349 EAW89350 EAW89351 EAW89352 Q15067 AK095501 AK225897 AK291793 BAF84482 AK292965 BAF85654 AK296409 BAG59073 AK300447 BAG62169 AK308218 AM393156 CAL38034 BC008767 AAH08767 BC010425 AAH10425 BQ943492 BX537380 CAD97622 DC297086 S69189 AAB30019 U07866 AAA18595 X71440 CAA50574 XM_011524868 XP_011523170 XM_011524869 XP_011523171 NM_001185039 NP_001171968 NM_004035 NP_004026 NM_007292 NP_009223
Function Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA. {ECO:0000269|PubMed:17458872, ECO:0000269|PubMed:17603022}.
Subcellular Location Peroxisome.
Tissue Specificity Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart. {ECO:0000269|PubMed:17603022, ECO:0000269|PubMed:20195242}.
Top Pathways PPAR signaling pathway, Peroxisome, cAMP signaling pathway, alpha-Linolenic acid metabolism, Fatty acid degradation

ACOX1 CRISPR/Cas9 KO Plasmid (h) - sc-401690 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACOX1 HDR Plasmid (h) - sc-401690-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACOX1 Double Nickase Plasmid (h) - sc-401690-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACOX1 Double Nickase Plasmid (h2) - sc-401690-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACOX1 CRISPR Activation Plasmid (h) - sc-401690-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACOX1 CRISPR Activation Plasmid (h2) - sc-401690-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACOX1 Lentiviral Activation Particles (h) - sc-401690-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACOX1 Lentiviral Activation Particles (h2) - sc-401690-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACOX1 siRNA (h) - sc-94104 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ACOX1 shRNA Plasmid (h) - sc-94104-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ACOX1 shRNA (h) Lentiviral Particles - sc-94104-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ACOX1 RNAi - H00000051-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ACOX1 RNAi - H00000051-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU113201 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2187 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2187 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ACOX1 siRNA (Human) - CRH0039 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ACOX1 - MBS8212088 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ACOX1 (NM_004035.6) - SHH230502 from Creative biogene

Category siRNA
Species Reactivities Human

ACOX1 shRNA Plasmid (Human) - CHH0039 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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