| Gene Symbol | ACOX1 |
|---|---|
| Entrez Gene | 51 |
| Alt Symbol | ACOX, PALMCOX, SCOX |
| Species | Human |
| Gene Type | protein-coding |
| Description | acyl-CoA oxidase 1, palmitoyl |
| Other Description | AOX|acyl-CoA oxidase, straight-chain|acyl-Coenzyme A oxidase 1, palmitoyl|palmitoyl-CoA oxidase|peroxisomal acyl-coenzyme A oxidase 1|peroxisomal fatty acyl-CoA oxidase|straight-chain acyl-CoA oxidase |
| Swissprots | Q9UD31 Q15068 Q15101 A8KAA0 A8K6X8 Q16131 Q7Z3W5 B4DK61 Q12863 F5GYQ8 Q15067 |
| Accessions | AAA19113 AAA19114 CBF60587 CBF65740 CBF73135 CBU85830 CBU90611 CBU96027 EAW89349 EAW89350 EAW89351 EAW89352 Q15067 AK095501 AK225897 AK291793 BAF84482 AK292965 BAF85654 AK296409 BAG59073 AK300447 BAG62169 AK308218 AM393156 CAL38034 BC008767 AAH08767 BC010425 AAH10425 BQ943492 BX537380 CAD97622 DC297086 S69189 AAB30019 U07866 AAA18595 X71440 CAA50574 XM_011524868 XP_011523170 XM_011524869 XP_011523171 NM_001185039 NP_001171968 NM_004035 NP_004026 NM_007292 NP_009223 |
| Function | Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA. {ECO:0000269|PubMed:17458872, ECO:0000269|PubMed:17603022}. |
| Subcellular Location | Peroxisome. |
| Tissue Specificity | Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart. {ECO:0000269|PubMed:17603022, ECO:0000269|PubMed:20195242}. |
| Top Pathways | PPAR signaling pathway, Peroxisome, cAMP signaling pathway, alpha-Linolenic acid metabolism, Fatty acid degradation |