| Gene Symbol | GOT1 |
|---|---|
| Entrez Gene | 100060793 |
| Alt Symbol | - |
| Species | Horse |
| Gene Type | protein-coding |
| Description | glutamic-oxaloacetic transaminase 1, soluble |
| Other Description | aspartate aminotransferase cytoplasmic-like protein|glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) |
| Swissprots | P08906 |
| Accessions | HQ889957 AEB61112 XM_001501044 XP_001501094 |
| Function | Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. |
| Top Pathways | Cysteine and methionine metabolism, Alanine, aspartate and glutamate metabolism, Tyrosine metabolism, Arginine and proline metabolism, Biosynthesis of amino acids |
Recombinant Horse Aspartate aminotransferase, cytoplasmic(GOT1) - CSB-YP009679HO CSB-EP009679HO CSB-BP009679HO CSB-MP009679HO from Cusabio
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Aspartate aminotransferase, cytoplasmic(GOT1) , Recombinant Protein - MBS950994 from MyBioSource
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