| Gene Symbol |
SPARC
|
| Entrez Gene |
386571
|
| Alt Symbol |
-
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
secreted protein, acidic, cysteine-rich (osteonectin)
|
| Other Description |
BM-40|ON|basement-membrane protein 40|osteonectin|secreted protein acidic and rich in cysteine
|
| Swissprots |
P36377
|
| Accessions |
P36377 L24906 AAA16893 NM_204410 NP_989741
|
| Function |
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Note=In or around the basement membrane. {ECO:0000250}.
|
| Tissue Specificity |
Detected in aorta, skeletal muscle, calvarium, vertebra, anterior limb, kidney, heart, brain, skin and lung. {ECO:0000269|PubMed:7916692}.
|