| Gene Symbol |
SENP6
|
| Entrez Gene |
26054
|
| Alt Symbol |
SSP1, SUSP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SUMO1/sentrin specific peptidase 6
|
| Other Description |
2810017C20Rik|SUMO-1-specific protease 1|SUMO1/sentrin specific protease 6|sentrin-specific protease 6|sentrin/SUMO-specific protease SENP6
|
| Swissprots |
Q5VUL4 Q9UJV5 Q5VUL3 O94891 Q9GZR1 A6NNY9 Q8TBY4
|
| Accessions |
CCQ43516 CCQ43517 EAW48733 EAW48734 EAW48735 EAW48736 Q9GZR1 AA768785 AB018340 BAA34517 AF196304 AAF04852 AF306508 AAG30253 AF307849 AAG29831 AI732829 AJ710192 AK001406 BAG50906 AK021417 BAG51032 AK021949 BAG51063 AK096455 BAC04794 AK126921 BAG54398 BC028583 AAH28583 CR990444 XM_006715457 XP_006715520 XM_011535745 XP_011534047 XM_011535746 XP_011534048 XM_011535747 XP_011534049 XR_241847 NM_001100409 NP_001093879 NM_001304792 NP_001291721 NM_015571 NP_056386
|
| Function |
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly- SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875}.
|
| Tissue Specificity |
Highly expressed in reproductive organs, such as testis, ovary and prostate.
|