SENP6

Gene Symbol SENP6
Entrez Gene 26054
Alt Symbol SSP1, SUSP1
Species Human
Gene Type protein-coding
Description SUMO1/sentrin specific peptidase 6
Other Description 2810017C20Rik|SUMO-1-specific protease 1|SUMO1/sentrin specific protease 6|sentrin-specific protease 6|sentrin/SUMO-specific protease SENP6
Swissprots Q5VUL4 Q9UJV5 Q5VUL3 O94891 Q9GZR1 A6NNY9 Q8TBY4
Accessions CCQ43516 CCQ43517 EAW48733 EAW48734 EAW48735 EAW48736 Q9GZR1 AA768785 AB018340 BAA34517 AF196304 AAF04852 AF306508 AAG30253 AF307849 AAG29831 AI732829 AJ710192 AK001406 BAG50906 AK021417 BAG51032 AK021949 BAG51063 AK096455 BAC04794 AK126921 BAG54398 BC028583 AAH28583 CR990444 XM_006715457 XP_006715520 XM_011535745 XP_011534047 XM_011535746 XP_011534048 XM_011535747 XP_011534049 XR_241847 NM_001100409 NP_001093879 NM_001304792 NP_001291721 NM_015571 NP_056386
Function Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly- SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}.
Subcellular Location Nucleus {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875}.
Tissue Specificity Highly expressed in reproductive organs, such as testis, ovary and prostate.

SENP6 CRISPR/Cas9 KO Plasmid (h) - sc-404246 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SENP6 HDR Plasmid (h) - sc-404246-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SENP6 Double Nickase Plasmid (h) - sc-404246-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SENP6 Double Nickase Plasmid (h2) - sc-404246-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SENP6 CRISPR Activation Plasmid (h) - sc-404246-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SENP6 CRISPR Activation Plasmid (h2) - sc-404246-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SENP6 Lentiviral Activation Particles (h) - sc-404246-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SENP6 Lentiviral Activation Particles (h2) - sc-404246-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SENP6 siRNA (h) - sc-61524 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SENP6 shRNA Plasmid (h) - sc-61524-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SENP6 shRNA (h) Lentiviral Particles - sc-61524-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SENP6 RNAi - H00026054-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU082981 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19089 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19089 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SENP6 siRNA (Human) - CRH8684 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SENP6 RNAi - H00026054-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SENP6 - MBS8209649 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SENP6 (NM_015571.2) - SHH404504 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SENP6(NM_015571.2) - SHR214744 from Creative biogene

Category siRNA
Species Reactivities Human

Human SENP6 siRNA - orb269186 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SENP6 shRNA Plasmid (Human) - CHH8684 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SENP6 miRNA 3'UTR clone - MiUTR1H-09265 from Creative biogene

Species Reactivities Human
Search more