| Gene Symbol |
Esr2
|
| Entrez Gene |
25149
|
| Alt Symbol |
ER-beta, ERbeta, Erb2
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
estrogen receptor 2 (ER beta)
|
| Other Description |
estrogen receptor 2 beta|estrogen receptor beta|nuclear receptor subfamily 3 group A member 2
|
| Swissprots |
O55015 Q62986 Q9R185 O35785 O70195 O35784 O55016
|
| Accessions |
CAA05631 CAA05632 EDM03650 EDM03651 EDM03652 EDM03653 Q62986 AB012721 BAA25431 AB190769 BAD91173 AB190770 BAD91174 AB530987 BAI48779 AF042058 AAB97424 AF042059 AAB97425 AF042060 AAB97426 AF042061 AAB97427 AF161187 AAD47637 U57439 AAC52602 XM_006240221 XP_006240283 NM_012754 NP_036886
|
| Function |
Binds estrogens with an affinity similar to that of ER- alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 3 and isoform 4 are unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. Isoform 2 shows loss of ligand binding affinity and suppresses ER- alpha and ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Expressed in prostate, ovary, lung, liver, kidney, fat, bone, brain, uterus and testis.
|
| Top Pathways |
Prolactin signaling pathway, Estrogen signaling pathway
|