Esr2

Gene Symbol	Esr2
Entrez Gene	25149
Alt Symbol	ER-beta, ERbeta, Erb2
Species	Rat
Gene Type	protein-coding
Description	estrogen receptor 2 (ER beta)
Other Description	estrogen receptor 2 beta\|estrogen receptor beta\|nuclear receptor subfamily 3 group A member 2
Swissprots	O55015 Q62986 Q9R185 O35785 O70195 O35784 O55016
Accessions	CAA05631 CAA05632 EDM03650 EDM03651 EDM03652 EDM03653 Q62986 AB012721 BAA25431 AB190769 BAD91173 AB190770 BAD91174 AB530987 BAI48779 AF042058 AAB97424 AF042059 AAB97425 AF042060 AAB97426 AF042061 AAB97427 AF161187 AAD47637 U57439 AAC52602 XM_006240221 XP_006240283 NM_012754 NP_036886
Function	Binds estrogens with an affinity similar to that of ER- alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 3 and isoform 4 are unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. Isoform 2 shows loss of ligand binding affinity and suppresses ER- alpha and ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action.
Subcellular Location	Nucleus.
Tissue Specificity	Expressed in prostate, ovary, lung, liver, kidney, fat, bone, brain, uterus and testis.
Top Pathways	Prolactin signaling pathway, Estrogen signaling pathway

Category	Protein
Source	Yeast or E.coli or Baculovirus or Mammalian cell
Species	Rat

Category	Protein
Prices	$1,320.00, $1,320.00, $1,540.00, $1,540.00, $2,180.00, $2,180.00, $2,645.00, $2,645.00
Sizes	500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 1 mg (E-Coli), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source	E Coli or Yeast or Baculovirus or Mammalian Cell
Species	Rat

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