Gene Symbol | Tnfrsf1b |
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Entrez Gene | 21938 |
Alt Symbol | CD120b, TNF-R-II, TNF-R2, TNF-R75, TNF-alphaR2, TNFBR, TNFR80, TNFRII, TNFalpha-R2, Tnfr-1, Tnfr2, p75 |
Species | Mouse |
Gene Type | protein-coding |
Description | tumor necrosis factor receptor superfamily, member 1b |
Other Description | TNF receptor beta chain|TNF-RII|TNFR-II|p75 TNFR|p80 TNF-alpha receptor|tumor necrosis factor receptor 2|tumor necrosis factor receptor superfamily member 1B|tumor necrosis factor receptor type II |
Swissprots | P25119 P97893 O88734 |
Accessions | AAA85021 CAA60618 CAA74969 EDL29729 EDL29730 P25119 AK004752 BAB23533 AK004844 BAB23610 AK085490 AK140332 BAE24341 AK153301 BAE31883 AK155385 BAE33233 AK156996 AK170464 BC141405 AAI41406 BY489212 M59378 AAA40463 M60469 AAA39752 X76401 CAA53981 NM_011610 NP_035740 |
Function | Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Top Pathways | Cytokine-cytokine receptor interaction, Adipocytokine signaling pathway, Amyotrophic lateral sclerosis (ALS), TNF signaling pathway |
TNF-R2 CRISPR/Cas9 KO Plasmid (m) - sc-423443 from Santa Cruz Biotechnology
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TNF-R2 HDR Plasmid (m) - sc-423443-HDR from Santa Cruz Biotechnology
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TNF-R2 Double Nickase Plasmid (m) - sc-423443-NIC from Santa Cruz Biotechnology
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TNF-R2 Double Nickase Plasmid (m2) - sc-423443-NIC-2 from Santa Cruz Biotechnology
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TNF-R2 CRISPR Activation Plasmid (m) - sc-423443-ACT from Santa Cruz Biotechnology
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TNF-R2 CRISPR Activation Plasmid (m2) - sc-423443-ACT-2 from Santa Cruz Biotechnology
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TNF-R2 Lentiviral Activation Particles (m) - sc-423443-LAC from Santa Cruz Biotechnology
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TNF-R2 Lentiviral Activation Particles (m2) - sc-423443-LAC-2 from Santa Cruz Biotechnology
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TNF-R2 siRNA (m) - sc-36690 from Santa Cruz Biotechnology
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TNF-R2 shRNA Plasmid (m) - sc-36690-SH from Santa Cruz Biotechnology
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TNF-R2 shRNA (m) Lentiviral Particles - sc-36690-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU070431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN43235 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43235 from Sigma-Aldrich
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TNFRSF1B siRNA (Mouse) - CRM4185 from Cohesion Biosciences
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TNFRSF1B - MBS8202955 from MyBioSource
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shRNA set against Mouse TNFRSF1B (NM_011610.3) - SHH431996 from Creative biogene
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shRNA set against Mouse Tnfrsf1b(NM_011610.3) - SHL084908 from Creative biogene
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Mouse TNFRSF1B siRNA - orb283661 from Biorbyt
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TNFRSF1B shRNA Plasmid (Mouse) - CHM4185 from Cohesion Biosciences
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TNFRSF1B miRNA 3'UTR clone - MiUTR1M-11995 from Creative biogene
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