| Gene Symbol |
Dnm2
|
| Entrez Gene |
25751
|
| Alt Symbol |
DYIIAAB
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
dynamin 2
|
| Other Description |
dynamin-2
|
| Swissprots |
P39052
|
| Accessions |
EDL78291 EDL78292 EDL78293 EDL78294 P39052 L24562 AAA16746 L25605 AAA19736 XM_006242604 XP_006242666 XM_006242605 XP_006242667 XM_006242608 XP_006242670 XM_006242610 XP_006242672 XM_006242611 XP_006242673 XM_006242612 XP_006242674 XM_006242613 XP_006242675 XM_006242614 XP_006242676 XM_008765917 XP_008764139 XM_008765918 XP_008764140 XM_008765919 XP_008764141 NM_013199 NP_037331
|
| Function |
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (PubMed:21210813). Plays an important role in vesicular trafficking processes, in particular endocytosis (PubMed:19995918). Involved in cytokinesis (PubMed:21195118). {ECO:0000269|PubMed:19995918, ECO:0000269|PubMed:21195118, ECO:0000269|PubMed:21210813}.
|
| Subcellular Location |
Isoform 4: Cell membrane.
|
| Tissue Specificity |
Ubiquitously expressed. Brain expression is restricted to glial cells and fibroblasts. Highest levels in the testis. {ECO:0000269|PubMed:9725914}.
|
| Top Pathways |
Fc gamma R-mediated phagocytosis, Endocytosis, Bacterial invasion of epithelial cells, Endocrine and other factor-regulated calcium reabsorption, Synaptic vesicle cycle
|