CTTN

Gene Symbol CTTN
Entrez Gene 2017
Alt Symbol EMS1
Species Human
Gene Type protein-coding
Description cortactin
Other Description 1110020L01Rik|amplaxin|ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)|oncogene EMS1|src substrate cortactin
Swissprots Q96H99 Q8N707 Q14247
Accessions AAB26248 BAD06416 EAW74766 EAW74767 EAW74768 EAW74769 EAW74770 Q14247 AA325227 AK023333 AK091778 BAG52416 AK222613 BAD96333 AK291097 BAF83786 AK304582 BAG65370 AU124856 BC008799 AAH08799 BC033889 AAH33889 DA716772 EU832619 ACE87710 EU832691 ACE87023 LN607836 CEF49523 M98343 AAA58455 XM_006718447 XP_006718510 XM_006718448 XP_006718511 NM_001184740 NP_001171669 NM_005231 NP_005222 NM_138565 NP_612632
Function Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12151401}. Cell projection, lamellipodium {ECO:0000269|PubMed:12151401}. Cell projection, ruffle. Cell projection, dendrite {ECO:0000250}. Cell projection {ECO:0000250|UniProtKB:Q66HL2}. Cell membrane {ECO:0000305|PubMed:17959782}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, podosome {ECO:0000250|UniProtKB:Q01406}. Cell junction {ECO:0000250|UniProtKB:Q66HL2}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q66HL2}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q66HL2}. Cell projection, dendritic spine {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000269|PubMed:12151401}. Note=Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation b
Top Pathways Tight junction, Pathogenic Escherichia coli infection, Bacterial invasion of epithelial cells, Proteoglycans in cancer

Phospho-Cortactin (Tyr421) Antibody - 4569 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa or NIH/3T3 cells, untreated or treated with hydrogen peroxide, using Phospho-Cortactin (Tyr421) Antibody in the presence of no peptide (A), a phospho-cortactin (Tyr421) peptide (B) or a nonphospho-cortactin peptide (C).

Cortactin (H222) Antibody - 3503 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using Cortactin (H222) Antibody.

Cortactin Antibody - 3502 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from C6, COS and HeLa cells, untreated or hydrogen peroxide (H2O2)-treated, using Cortactin Antibody.

Cortactin (A-4) - sc-55578 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cortactin (A-4): sc-55578. Western blot analysis of Cortactin expression in HeLa whole cell lysate.

Cortactin (H-1) - sc-271173 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cortactin (H-1): sc-271173. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of Islets of Langerhans and glandular cells.

Cortactin (F-14) - sc-30770 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cortactin (F-14): sc-30770. Western blot analysis of Cortactin expression in non-transfected: sc-117752 (A) and mouse Cortactin transfected: sc-126659 (B) 293T whole cell lysates.

Cortactin (E-4) - sc-55588 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cortactin (E-4): sc-55588. Western blot analysis of Cortactin expression in 804G (A) and KNRK (B) whole cell lysates.

Cortactin (G-18) - sc-30771 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cortactin (G-18): sc-30771. Western blot analysis of Cortactin expression in A-431 whole cell lysate.

Cortactin (G-20) - sc-6544 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cortactin (G-20): sc-6544. Western blot analysis of Cortactin expression in non-transfected: sc-117752 (A) and mouse Cortactin transfected: sc-126659 (B) 293T whole cell lysates.

Cortactin (H-5) - sc-55579 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cortactin (H-5): sc-55579. Western blot analysis of Cortactin expression in HeLa whole cell lysate.

Cortactin (H-191) - sc-11408 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Cortactin (H-191): sc-11408. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing cytoplasmic staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Cortactin (M-19) - sc-30772 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cortactin (M-19): sc-30772. Western blot analysis of Cortactin expression in BT-20 (A) and MCF7 (B) whole cell lysates.

Cortactin (30) - sc-136134 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Cortactin (30): sc-136134. Western blot analysis of Cortactin expression in A-431 whole cell lysate.

p-Cortactin (Tyr 466) - sc-101661 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-Cortactin (Tyr 466): sc-101661. Western blot analysis of phosphorylated Cortactin expression in untreated (A) and UV-treated (B) HeLa whole cell lysates.

Anti-Cortactin (phospho Y421) antibody - ab47768 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cortactin (phospho Y421) antibody (ab47768) at 1/500 dilutionLane 1 : Hela cell extract, treated with H2O2Lane 2 : Hela cell extract, untreated

Anti-Cortactin (phospho Y421) antibody - ab196038 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cortactin (phospho Y421) antibody (ab196038) at 1/500 dilutionLane 1 : H2O2 treated HeLa whole cell lysates with antigen specific peptideLane 2 : H2O2 treated HeLa whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-Cortactin (phospho Y466) antibody - ab51073 from Abcam

Prices $369.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cortactin (phospho Y466) antibody (ab51073) at 1/500 dilutionLane 1 : Cos 7 cell extract with phosphopeptideLane 2 : Cos 7 cell extract without phosphopeptide

Anti-Cortactin (phospho Y466) antibody - ab196042 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cortactin (phospho Y466) antibody (ab196042) at 1/500 dilutionLane 1 : COS7 whole cell lysate with antigen-specific peptideLane 2 : COS7 whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-Cortactin antibody - ab152149 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Cortactin antibody (ab152149) at 1/10000 dilution + H1299 whole cell lysate at 30 µg

Anti-Cortactin antibody - ab93796 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling Cortactin with ab93796 at 1/1000 (0.2µg/ml). Detection: DAB.

Anti-Cortactin antibody - ab85507 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Cortactin antibody (ab85507) at 1/100 dilution + HL60 cell line lysates at 35 µg

Anti-Cortactin antibody - ab47582 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cortactin antibody (ab47582) at 1/500 dilutionLane 1 : Extracts from Hela cells treated with hydrogen peroxide.Lane 2 : Extracts from Hela cells treated with hydrogen peroxide and immunogenic peptide.Lysates/proteins at 30 µg per lane.

Anti-Cortactin antibody - ab51101 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cortactin antibody (ab51101) at 1/500 dilutionLane 1 : Cos-7 cell extractLane 2 : Cos-7 cell extract and immunizing peptide

Anti-Cortactin antibody - ab116554 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Cortactin antibody (ab116554) at 1/100 dilution + HeLa cell lysate at 35 µg

Anti-Cortactin antibody - ab1374 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-Cortactin antibody (ab1374) at 0.1 µg/ml + Lysate prepared from mouse brain tissue at 35 µgdeveloped using the ECL technique
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