| Gene Symbol | CTTN |
|---|---|
| Entrez Gene | 2017 |
| Alt Symbol | EMS1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cortactin |
| Other Description | 1110020L01Rik|amplaxin|ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)|oncogene EMS1|src substrate cortactin |
| Swissprots | Q96H99 Q8N707 Q14247 |
| Accessions | AAB26248 BAD06416 EAW74766 EAW74767 EAW74768 EAW74769 EAW74770 Q14247 AA325227 AK023333 AK091778 BAG52416 AK222613 BAD96333 AK291097 BAF83786 AK304582 BAG65370 AU124856 BC008799 AAH08799 BC033889 AAH33889 DA716772 EU832619 ACE87710 EU832691 ACE87023 LN607836 CEF49523 M98343 AAA58455 XM_006718447 XP_006718510 XM_006718448 XP_006718511 NM_001184740 NP_001171669 NM_005231 NP_005222 NM_138565 NP_612632 |
| Function | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12151401}. Cell projection, lamellipodium {ECO:0000269|PubMed:12151401}. Cell projection, ruffle. Cell projection, dendrite {ECO:0000250}. Cell projection {ECO:0000250|UniProtKB:Q66HL2}. Cell membrane {ECO:0000305|PubMed:17959782}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, podosome {ECO:0000250|UniProtKB:Q01406}. Cell junction {ECO:0000250|UniProtKB:Q66HL2}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q66HL2}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q66HL2}. Cell projection, dendritic spine {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000269|PubMed:12151401}. Note=Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation b |
| Top Pathways | Tight junction, Pathogenic Escherichia coli infection, Bacterial invasion of epithelial cells, Proteoglycans in cancer |
Cortactin CRISPR/Cas9 KO Plasmid (h) - sc-400761 from Santa Cruz Biotechnology
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Cortactin HDR Plasmid (h) - sc-400761-HDR from Santa Cruz Biotechnology
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Cortactin Double Nickase Plasmid (h) - sc-400761-NIC from Santa Cruz Biotechnology
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Cortactin Double Nickase Plasmid (h2) - sc-400761-NIC-2 from Santa Cruz Biotechnology
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Cortactin CRISPR Activation Plasmid (h) - sc-400761-ACT from Santa Cruz Biotechnology
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Cortactin CRISPR Activation Plasmid (h2) - sc-400761-ACT-2 from Santa Cruz Biotechnology
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Cortactin Lentiviral Activation Particles (h) - sc-400761-LAC from Santa Cruz Biotechnology
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Cortactin Lentiviral Activation Particles (h2) - sc-400761-LAC-2 from Santa Cruz Biotechnology
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Cortactin siRNA (h) - sc-35093 from Santa Cruz Biotechnology
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Cortactin shRNA Plasmid (h) - sc-35093-SH from Santa Cruz Biotechnology
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Cortactin shRNA (h) Lentiviral Particles - sc-35093-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU093121 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6761 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09305 from Sigma-Aldrich
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CTTN siRNA (Human) - CRH1398 from Cohesion Biosciences
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CTTN - MBS8213127 from MyBioSource
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shRNA set against Human CTTN (NM_005231.3) - SHH271697 from Creative biogene
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shRNA set against Human CTTN(NM_005231.3) - SHG211191 from Creative biogene
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Human CTTN siRNA - orb261900 from Biorbyt
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CTTN shRNA Plasmid (Human) - CHH1398 from Cohesion Biosciences
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CTTN miRNA 3'UTR clone - MiUTR1H-02548 from Creative biogene
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CTTN miRNA 3'UTR clone - MiUTR3H-01599 from Creative biogene
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