DICER1

Gene Symbol	DICER1
Entrez Gene	23405
Alt Symbol	DCR1, Dicer, Dicer1e, HERNA, K12H4.8-LIKE, MNG1, RMSE2
Species	Human
Gene Type	protein-coding
Description	dicer 1, ribonuclease type III
Other Description	Dicer1, Dcr-1 homolog|dicer 1, double-stranded RNA-specific endoribonuclease|endoribonuclease Dicer|helicase MOI|helicase with RNAse motif
Swissprots	E0AD28 Q9UQ02 B3KRG4 A7E2D3 Q9UPY3 O95943
Accessions	CBM42912 CBV35645 EAW81595 EAW81596 Q9UPY3 AB023145 BAA76772 AB028449 BAA78691 AF007142 AJ132261 CAB38857 AK001041 AK001827 AK002007 BAG51002 AK091094 AK091513 BAG52376 AL122105 CAB59269 AL832389 AW297296 AY845867 AAW31883 AY845868 AAW31884 AY929254 AAX18334 AY929255 AAX18335 AY929256 AAX18336 BC046934 BC068591 BC150287 AAI50288 BI913232 BM152875 BP199059 BQ937506 HM595745 ADK25182 KJ175111 AIK25433 XM_011536599 XP_011534901 XM_011536600 XP_011534902 XM_011536601 XP_011534903 XM_011536602 XP_011534904 XM_011536603 XP_011534905 XM_011536604 XP_011534906 XM_011536605 XP_011534907 NM_001195573 NP_001182502 NM_001271282 NP_001258211 NM_001291628 NP_001278557 NM_030621 NP_085124 NM_177438 NP_803187
Function	Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMe
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16424907}.
Top Pathways	MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Dicer peptide - ab24556 from Abcam Category Peptide

Human Dicer protein fragment - ab92268 from Abcam Category Protein Source E. coli Species Human

Mouse Dicer peptide - ab24555 from Abcam Category Peptide Species Mouse

DICER1 / Dicer Blocking Peptide - LS-E25923 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Dicer Partial Recombinant Protein - H00023405-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Dicer Blocking Peptide - 33R-10886 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

DICER1 - H00023405-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DICER1 - H00023405-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DICER1 control peptide - AP00338CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

Recombinant Human DICER1, His-tagged - DICER1-28329TH from Creative Biomart Category Protein Source E. coli

Recombinant Human DICER1 - DICER1-784H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human DICER1, GST-tagged - DICER1-4738H from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Dicer 1, Ribonuclease Type III (DICER1) - RPK448Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Dicer 1, Ribonuclease Type III (DICER1) - RPK448Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Endoribonuclease Dicer(DICER1) ,partial - CSB-YP891575HU CSB-EP891575HU CSB-BP891575HU CSB-MP891575HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Dicer Blocking Peptide - 3697BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

DICER1 Peptide (OEEG01170) - OEEG01170 from Aviva Systems Biology Category Peptide Prices $150.00 Sizes 50 µg

DICER1 (transcript variant 2) - TP311804 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DICER1 (transcript variant 1) - TP319214 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Dicer, Peptide - MBS843577 from MyBioSource Category Peptide Prices $165.00 Sizes 50 µg

DICER1, Peptide - MBS396406 from MyBioSource Category Peptide Prices $195.00 Sizes 50 µg

Dicer1-Antibody-C-term-Blocking-Peptide - BP1901b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Dicer1-Antibody-C-term-A1895-Blocking-Peptide - BP1901a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Dicer1-Antibody-Center-Blocking-Peptide - BP1901c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DICER1 Peptide, Human - M34GP04304H from Creative Peptides Category Peptide Source Synthetic. Species Human

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